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4,7-Dichloro[1,2,5]oxadiazolo[3,4-d]pyridazine 1-oxide
Open AccessFeature PaperShort Note

Dimethyl 2,2′-[Carbonylbis(azanediyl)](2S,2′S)-bis[3-(4-hydroxyphenyl)propanoate]

Laboratory of Industrial and Synthetic Organic Chemistry, Department of Chemistry and Chemical Technologies, University of Calabria, Via Pietro Bucci 12/C, 87036 Arcavacata di Rende (CS), Italy
Università degli Studi di Palermo, Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche-STEBICEF, Viale delle Scienze Ed.17, 90128, Palermo, Italy
Department of Chemistry, Life Sciences and Environmental Sustainability (SCVSA), University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy
Department of Industrial Chemistry “T. Montanari”, University of Bologna, Viale Risorgimento 4, 40136 Bologna, Italy
Authors to whom correspondence should be addressed.
Molbank 2018, 2018(1), M983;
Received: 30 January 2018 / Revised: 14 February 2018 / Accepted: 16 February 2018 / Published: 19 February 2018
(This article belongs to the Special Issue Molecules from Catalytic Processes)
The thus-far unknown ureic derivative dimethyl 2,2′-[carbonylbis(azanediyl)](2S,2′S)-bis[3-(4-hydroxyphenyl)propanoate] has been efficiently synthesized by enantiospecific oxidative carbonylation of readily available l-tyrosine methyl ester, using a very simple catalytic system (PdI2 in conjunction with KI) under relatively mild conditions (100 °C for 5 h in DME as the solvent and under 20 atm of a 4:1 mixture CO-air). View Full-Text
Keywords: carbonylation; palladium; l-tyrosine methyl ester; ureas carbonylation; palladium; l-tyrosine methyl ester; ureas
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MDPI and ACS Style

Mancuso, R.; Gioia, K.F.; Piccionello, A.P.; Della Ca’, N.; Carfagna, C.; Gabriele, B. Dimethyl 2,2′-[Carbonylbis(azanediyl)](2S,2′S)-bis[3-(4-hydroxyphenyl)propanoate]. Molbank 2018, 2018, M983.

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