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Department of Chemical Analysis, AKA Bogor Polytechnic, Bogor 16154, West Java, Indonesia
Faculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, Indonesia
Author to whom correspondence should be addressed.
Molbank 2017, 2017(3), M949;
Received: 18 June 2017 / Revised: 23 July 2017 / Accepted: 31 July 2017 / Published: 3 August 2017
(This article belongs to the Section Organic Synthesis)
A novel di-Mannich derivative of curcumin pyrazole, 2-[(2,6-dimethyl morpholin-4-yl)methyl]-4-[(E)-2-{3-[(E)-2-{3-[(2,6-dimethylmorpholin-4-yl)methyl]-4-hydroxy-5-methoxyphenyl}ethenyl]-1H-pyrazol-5-yl}ethenyl]-6-methoxyphenol (2), has been synthesized through a Mannich reaction of curcumin pyrazole (1), formaldehyde, and 2,6-dimethylmorpholine. The structure of the synthesized compound was confirmed on the basis of FTIR, 1H-NMR, 13C-NMR, 2D Heteronuclear Single-Quantum Correlation (HSQC) and 2D Heteronuclear Multiple Bond Correlation (HMBC), and mass spectral data. The water solubility was evaluated and the result showed that compound 2 was three times more soluble than that of curcumin pyrazole (1) and curcumin. View Full-Text
Keywords: di-Mannich derivative; curcumin pyrazole; 2,6-dimethylmorpholine; water solubility di-Mannich derivative; curcumin pyrazole; 2,6-dimethylmorpholine; water solubility
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Untung, J.; Iskandarsyah, I.; Hayun, H. 2-[(2,6-Dimethylmorpholin-4-yl)methyl]-4-[(E)-2-{3-[(E)-2-{3-[(2,6-dimethylmorpholin-4-yl)methyl]-4-hydroxy-5-methoxyphenyl}ethenyl]-1H-pyrazol-5-yl}ethenyl]-6-methoxyphenol. Molbank 2017, 2017, M949.

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