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Molbank 2016, 2016(4), M919;

3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester

School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
Author to whom correspondence should be addressed.
Academic Editor: Norbert Haider
Received: 2 November 2016 / Revised: 22 November 2016 / Accepted: 22 November 2016 / Published: 29 November 2016
(This article belongs to the Section Organic Synthesis)
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An efficient procedure to obtain the new compound 1a from ethyl acetoacetate (2a), NBS and N,N′-diethylthiourea (4a) was reported. In comparison with the traditional method to synthesize its analogues, this efficient, catalyst-free, and one-pot synthetic method is facile. The work-up procedure is easy and gives the pure target compound under milder reaction conditions in a relatively high yield of 75%. View Full-Text
Keywords: 2,3-dihydro-1,3-thiazole; one-pot synthesis; N,N′-diethylthiourea 2,3-dihydro-1,3-thiazole; one-pot synthesis; N,N′-diethylthiourea
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Meng, G.; Wang, M.; Cheng, Y.-N.; Chen, K.; Tong, J.; Zhang, J.-H. 3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester. Molbank 2016, 2016, M919.

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