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Molbank 2015, 2015(3), M866;


Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala Biomedical Center, Uppsala University, P. O. Box 574, SE-751 23 Uppsala, Sweden
Author to whom correspondence should be addressed.
Received: 30 April 2015 / Revised: 30 June 2015 / Accepted: 1 July 2015 / Published: 10 July 2015
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A one-pot, direct synthesis of 3,4-dihydro-3-(2-hydroxyethyl)-4-(nitromethyl)quinazolin-2(1H)-one from methyl (2-formylphenyl)carbamate, ethanolamine and nitromethane in AcOH is reported. The reaction proceeds via a cascade three-component aza-Henry reaction under microwave irradiation and the title compound was characterized by 1H NMR, 13C NMR and ESI/MS analysis. View Full-Text
Keywords: multicomponent reaction; aza-Henry; 3,4-dihydroquinazolinone multicomponent reaction; aza-Henry; 3,4-dihydroquinazolinone

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Sawant, R.T.; Stevens, M.Y.; Odell, L.R. 3,4-Dihydro-3-(2-hydroxyethyl)-4-(nitromethyl)quinazolin-2(1H)-one. Molbank 2015, 2015, M866.

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