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3,4-Dihydro-3-(2-hydroxyethyl)-4-(nitromethyl)quinazolin-2(1H)-one

Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala Biomedical Center, Uppsala University, P. O. Box 574, SE-751 23 Uppsala, Sweden
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Molbank 2015, 2015(3), M866; https://doi.org/10.3390/M866
Received: 30 April 2015 / Revised: 30 June 2015 / Accepted: 1 July 2015 / Published: 10 July 2015
A one-pot, direct synthesis of 3,4-dihydro-3-(2-hydroxyethyl)-4-(nitromethyl)quinazolin-2(1H)-one from methyl (2-formylphenyl)carbamate, ethanolamine and nitromethane in AcOH is reported. The reaction proceeds via a cascade three-component aza-Henry reaction under microwave irradiation and the title compound was characterized by 1H NMR, 13C NMR and ESI/MS analysis. View Full-Text
Keywords: multicomponent reaction; aza-Henry; 3,4-dihydroquinazolinone multicomponent reaction; aza-Henry; 3,4-dihydroquinazolinone
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MDPI and ACS Style

Sawant, R.T.; Stevens, M.Y.; Odell, L.R. 3,4-Dihydro-3-(2-hydroxyethyl)-4-(nitromethyl)quinazolin-2(1H)-one. Molbank 2015, 2015, M866.

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