Next Article in Journal
Accelerator Analysis of Tributyltin Adsorbed onto the Surface of a Tributyltin Resistant Marine Pseudoalteromonas sp. Cell
Previous Article in Journal
Prediction of Human Intestinal Absorption by GA Feature Selection and Support Vector Machine Regression
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2008, 9(10), 1977-1988;

Elevation of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in the Mouse Brain after Chronic Nonylphenol Exposure

School of Environment Science and Spatial Informatics, China University of Mining and Technology, Xuzhou 221008, Jiangsu Province, P.R. China
Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Xuzhou Normal University, Xuzhou 221116, Jiangsu Province, P.R. China
Author to whom correspondence should be addressed.
Received: 21 March 2008 / Revised: 9 October 2008 / Accepted: 13 October 2008 / Published: 24 October 2008
(This article belongs to the Section Biochemistry)
Full-Text   |   PDF [246 KB, uploaded 19 June 2014]   |  


The present study was performed to investigate the effects of chronic administration of nonylphenol (NP) on the expression of inflammation-related genes in the brains of mice. NP was given orally by gavages at 0, 50, 100, and 200 mg/kg/d. The expression of inflammatory enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), was evaluated by immunohistochemistry and immunoblotting assays. The nitric oxide (NO) level and nitric oxide synthase (NOS) activity were also measured by biochemical analyses. The results showed that NP at a high dose (200 mg/kg/d) significantly increased the expression of iNOS and COX-2 in both the hippocampus and cortex. In parallel with the increase in iNOS expression, the NO level was significantly greater at the dose of 200 mg/kg/d, compared to the control. The activity of NOS was also increased in the brain of mice at the dose of 100 and 200 mg/kg/d. These findings demonstrate that NP may have the potential to induce the chronic inflammation or cause neurotoxicity in the mouse brain. View Full-Text
Keywords: Nonylphenol; iNOS; COX-2; NO; brain Nonylphenol; iNOS; COX-2; NO; brain

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Zhang, Y.-Q.; Mao, Z.; Zheng, Y.-L.; Han, B.-P.; Chen, L.-T.; Li, J.; Li, F. Elevation of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in the Mouse Brain after Chronic Nonylphenol Exposure. Int. J. Mol. Sci. 2008, 9, 1977-1988.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top