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Volume 27
Issue 13
10.3390/ijms27135797
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

The Mutational Landscape of Acute Myeloid Leukemia and Its Impact

by
Tarindhi Ratnayake
1,
Clifford Liongue
1,2 and
Alister C. Ward
1,2,*
1
School of Medicine, Deakin University, Waurn Ponds, Geelong, VIC 3216, Australia
2
Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Waurn Ponds, Geelong, VIC 3216, Australia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2026, 27(13), 5797; https://doi.org/10.3390/ijms27135797
Submission received: 15 May 2026 / Revised: 19 June 2026 / Accepted: 24 June 2026 / Published: 26 June 2026
(This article belongs to the Special Issue Molecular Studies of Hematologic Malignancies)
Versions Notes

Abstract

Acute myeloid leukemia (AML) is one of the most common types of hematological malignancies and a leading cause of cancer deaths. It is characterized by the rapid accumulation of typically immature myeloid cells that serve to disrupt the production of mature cells, leading to a range of clinical sequelae. The role of recurrent chromosomal aberrations has long been appreciated in this disease, but a myriad of gene mutations have been increasingly acknowledged as having important roles. This review provides a comprehensive overview of the mutational landscape of AML, discussing the various genetic lesions in terms of their function, classification, etiological role, prognostic value, therapeutic impact, detection, and monitoring, with a particular focus on gene mutations.
Keywords: acute myeloid leukemia; mutations acute myeloid leukemia; mutations

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MDPI and ACS Style

Ratnayake, T.; Liongue, C.; Ward, A.C. The Mutational Landscape of Acute Myeloid Leukemia and Its Impact. Int. J. Mol. Sci. 2026, 27, 5797. https://doi.org/10.3390/ijms27135797

AMA Style

Ratnayake T, Liongue C, Ward AC. The Mutational Landscape of Acute Myeloid Leukemia and Its Impact. International Journal of Molecular Sciences. 2026; 27(13):5797. https://doi.org/10.3390/ijms27135797

Chicago/Turabian Style

Ratnayake, Tarindhi, Clifford Liongue, and Alister C. Ward. 2026. "The Mutational Landscape of Acute Myeloid Leukemia and Its Impact" International Journal of Molecular Sciences 27, no. 13: 5797. https://doi.org/10.3390/ijms27135797

APA Style

Ratnayake, T., Liongue, C., & Ward, A. C. (2026). The Mutational Landscape of Acute Myeloid Leukemia and Its Impact. International Journal of Molecular Sciences, 27(13), 5797. https://doi.org/10.3390/ijms27135797

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