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Volume 27
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10.3390/ijms27114794
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Biomineral Complex with Probiotic and Detoxifying Properties for Recovery After Radiotherapy

by
Olga Ilinskaya
1,*,
Konstantin Vagin
2,
William Kurdy
1,
Galina Yakovleva
1,
Nazira Karamova
1,
Pavel Zelenikhin
1,
Alexey Kolpakov
1 and
Yuri Zuev
3
1
Department of Microbiology, Kazan (Volga-Region) Federal University, Kremlevskaya St., 18, Kazan 420008, Russia
2
Federal Center for Toxicological, Radiation and Biological Safety, Science City-2, Kazan 420075, Russia
3
Kazan Institute of Biochemistry and Biophysics of the Kazan Scientific Center of the Russian Academy of Sciences, Lobachevsky St., 2, Kazan 420111, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2026, 27(11), 4794; https://doi.org/10.3390/ijms27114794
Submission received: 28 April 2026 / Revised: 18 May 2026 / Accepted: 25 May 2026 / Published: 26 May 2026
(This article belongs to the Special Issue Advanced Biomaterials for Tissue Regeneration)
Versions Notes

Abstract

Radiotherapy is a highly effective, safe cancer treatment, and about half of all cancer treatments involve lifesaving radiotherapy. Despite huge advances in technology that have made it safer and more effective, it is still not without side effects. They differ from patient to patient and can include fatigue, nausea, skin reactions, and hair loss, but dysbiosis is the most common complication associated with radiotherapy. Probiotics aimed at restoring the microbiome have found widespread use, but the problem of their rapid inactivation in the gastrointestinal tract has not yet been solved. Our study aims to confirm the effectiveness of a novel biomineral complex, based on a powdered clinoptilolite containing a rock loaded with lactobacilli for restoring the intestinal microbiome of mice exposed to radiation. Based on the 16S rRNA gene analysis, alpha-diversity and dynamics of changes in the fecal metagenome, as well as the functional potential of mice exposed to radiation, were studied, and the prospects of administering the biomineral complex to achieve positive effects were assessed. NMR analysis of the mineral carrier was carried out, and its safety was confirmed. Moreover, per os administration of the complex following irradiation led to a reduction in the level of chromosomal aberrations induced by irradiation. Thus, the biomineral complex has a microbiome-restoring effect and reduces radiation-induced clastogenesis.
Keywords: radiotherapy; side effects; microbiome; chromosomal aberrations; clinoptilolite-containing carrier; Lactobacillaceae; alpha and beta diversity; functional analysis radiotherapy; side effects; microbiome; chromosomal aberrations; clinoptilolite-containing carrier; Lactobacillaceae; alpha and beta diversity; functional analysis

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MDPI and ACS Style

Ilinskaya, O.; Vagin, K.; Kurdy, W.; Yakovleva, G.; Karamova, N.; Zelenikhin, P.; Kolpakov, A.; Zuev, Y. Biomineral Complex with Probiotic and Detoxifying Properties for Recovery After Radiotherapy. Int. J. Mol. Sci. 2026, 27, 4794. https://doi.org/10.3390/ijms27114794

AMA Style

Ilinskaya O, Vagin K, Kurdy W, Yakovleva G, Karamova N, Zelenikhin P, Kolpakov A, Zuev Y. Biomineral Complex with Probiotic and Detoxifying Properties for Recovery After Radiotherapy. International Journal of Molecular Sciences. 2026; 27(11):4794. https://doi.org/10.3390/ijms27114794

Chicago/Turabian Style

Ilinskaya, Olga, Konstantin Vagin, William Kurdy, Galina Yakovleva, Nazira Karamova, Pavel Zelenikhin, Alexey Kolpakov, and Yuri Zuev. 2026. "Biomineral Complex with Probiotic and Detoxifying Properties for Recovery After Radiotherapy" International Journal of Molecular Sciences 27, no. 11: 4794. https://doi.org/10.3390/ijms27114794

APA Style

Ilinskaya, O., Vagin, K., Kurdy, W., Yakovleva, G., Karamova, N., Zelenikhin, P., Kolpakov, A., & Zuev, Y. (2026). Biomineral Complex with Probiotic and Detoxifying Properties for Recovery After Radiotherapy. International Journal of Molecular Sciences, 27(11), 4794. https://doi.org/10.3390/ijms27114794

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