Platelets Modulate Leukocyte Population Composition Within Perivascular Adipose Tissue
Abstract
1. Introduction
2. Results
2.1. Leukocyte PVAT Composition with Acute Western Diet Feeding
2.2. T and Myeloid Cell Subsets Within PVAT Following Acute Feeding
2.3. Platelet Modulation of Monocytes and Macrophages in PVAT After Acute Western Diet
2.4. PVAT Leukocyte Content After Extended Western Diet Feeding
2.5. Myeloid Cell Subsets Shifted with Extended Western Diet Feeding and Platelet Depletion
2.6. Platelets Influenced Monocyte and Macrophage Subsets with Extended Feeding
3. Discussion
4. Materials and Methods
4.1. Mouse Model and Diet Administration
4.2. Platelet Depletion
4.3. PVAT Collection and Processing
4.4. Flow Cytometry Preparation
4.5. Flow Cytometry Data Collection and Analysis
4.6. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Corken, A.; Weinkopff, T.; Wahl, E.C.; Sikes, J.D.; Thakali, K.M. Platelets Modulate Leukocyte Population Composition Within Perivascular Adipose Tissue. Int. J. Mol. Sci. 2025, 26, 1625. https://doi.org/10.3390/ijms26041625
Corken A, Weinkopff T, Wahl EC, Sikes JD, Thakali KM. Platelets Modulate Leukocyte Population Composition Within Perivascular Adipose Tissue. International Journal of Molecular Sciences. 2025; 26(4):1625. https://doi.org/10.3390/ijms26041625
Chicago/Turabian StyleCorken, Adam, Tiffany Weinkopff, Elizabeth C. Wahl, James D. Sikes, and Keshari M. Thakali. 2025. "Platelets Modulate Leukocyte Population Composition Within Perivascular Adipose Tissue" International Journal of Molecular Sciences 26, no. 4: 1625. https://doi.org/10.3390/ijms26041625
APA StyleCorken, A., Weinkopff, T., Wahl, E. C., Sikes, J. D., & Thakali, K. M. (2025). Platelets Modulate Leukocyte Population Composition Within Perivascular Adipose Tissue. International Journal of Molecular Sciences, 26(4), 1625. https://doi.org/10.3390/ijms26041625