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Endothelial Dysfunction in Huntington’s Disease: Pathophysiology and Therapeutic Implications

Int. J. Mol. Sci. 2025, 26(4), 1432; https://doi.org/10.3390/ijms26041432

by Ning Hu^1,†

, Zihao Chen^2,†, Xinyue Zhao¹, Xin Peng¹, Yimeng Wu¹, Kai Yang^1,3,*

and Taolei Sun^1,3,4,*

Reviewer 1:

Reviewer 2:

Int. J. Mol. Sci. 2025, 26(4), 1432; https://doi.org/10.3390/ijms26041432

Submission received: 15 January 2025 / Revised: 3 February 2025 / Accepted: 6 February 2025 / Published: 8 February 2025

(This article belongs to the Section Molecular Neurobiology)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The proposals for supplementing the manuscript are described in the attached report.

Comments for author File: Comments.pdf

Author Response

please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

1. please add references for the following line, 42, 58, 60

2. line 100-102, please add refs

3. line259 seems incomplete "sprout density"

4. table 1 and 2 can you maintain consistency with references style ex:instead of Hu et al, put[1]

5. 4.3 talks about several pharmacological agents are these agents 4.4 4.5 etc..?

if so instead of labeling them as separate sections label as 4.3.1.,4.3.2. this will avoid confusion.

6. line 370, 373, 383 add references for the statements.

7. 4.8 is conclusion and 5 is conclusion, can you rephrase this section?

8. please delete the comments for acknowledgement and funding

9. 3.2 in red, please correct

Author Response

please see the attachment

Author Response File: Author Response.pdf