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Volume 26
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10.3390/ijms26199659
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Review

Utilization of Stem Cells in Medicine: A Narrative Review

by
Banu Ismail Mendi
1,†,
Rahim Hirani
2,†,
Alyssa Sayegh
2,
Mariah Hassan
2,
Lauren Fleshner
2,
Banu Farabi
3,*,
Mehmet Fatih Atak
2,4,5,‡ and
Bijan Safai
2,4,*,‡
1
Department of Dermatology, Nigde Omer Halis Demir University, Niğde 51000, Türkiye
2
School of Medicine, New York Medical College, Valhalla, NY 10595, USA
3
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4
Department of Dermatology, NYC Health + Hospitals/Metropolitan, New York, NY 10029, USA
5
Department of Dermatology, NYC Health + Hospitals/South Brooklyn Health, New York, NY 11235, USA
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
Co-senior Authors.
Int. J. Mol. Sci. 2025, 26(19), 9659; https://doi.org/10.3390/ijms26199659
Submission received: 21 August 2025 / Revised: 21 September 2025 / Accepted: 1 October 2025 / Published: 3 October 2025
(This article belongs to the Special Issue Cutaneous Biology, Molecular Dermatology and Dermatopathology, 2nd Edition)
Review Reports Versions Notes

Abstract

Regenerative medicine holds significant promise for addressing diseases and irreversible damage that are challenging to treat with conventional methods, making it a prominent research focus in modern medicine. Research on stem cells, a key area within regenerative medicine due to their self-renewal capabilities, is expanding, positioning them as a novel therapeutic option. Stem cells, utilized in various treatments, are categorized based on their differentiation potential and the source tissue. The term ‘stem cell’ encompasses a broad spectrum of cells, which can be derived from embryonic tissues, adult tissues, or generated by reprogramming differentiated cells. These cells, applied across numerous medical disciplines including cardiovascular, neurological, and hematological disorders, as well as wound healing, demonstrate varying therapeutic applications based on their differentiation capacities, each presenting unique advantages and limitations. Nevertheless, the existing literature lacks a comprehensive synthesis examining stem cell therapy and its cellular subtypes across different medical specialties. This review addresses this lacuna by collectively categorizing contemporary stem cell research according to medical specialty and stem cell classification, offering an exhaustive analysis of their respective benefits and constraints, thereby elucidating multifaceted perspectives on the clinical implementation of this therapeutic modality.
Keywords: stem cells; regenerative medicine; embryonic tissue; cell therapy; pluripotency stem cells; regenerative medicine; embryonic tissue; cell therapy; pluripotency

Share and Cite

MDPI and ACS Style

Ismail Mendi, B.; Hirani, R.; Sayegh, A.; Hassan, M.; Fleshner, L.; Farabi, B.; Atak, M.F.; Safai, B. Utilization of Stem Cells in Medicine: A Narrative Review. Int. J. Mol. Sci. 2025, 26, 9659. https://doi.org/10.3390/ijms26199659

AMA Style

Ismail Mendi B, Hirani R, Sayegh A, Hassan M, Fleshner L, Farabi B, Atak MF, Safai B. Utilization of Stem Cells in Medicine: A Narrative Review. International Journal of Molecular Sciences. 2025; 26(19):9659. https://doi.org/10.3390/ijms26199659

Chicago/Turabian Style

Ismail Mendi, Banu, Rahim Hirani, Alyssa Sayegh, Mariah Hassan, Lauren Fleshner, Banu Farabi, Mehmet Fatih Atak, and Bijan Safai. 2025. "Utilization of Stem Cells in Medicine: A Narrative Review" International Journal of Molecular Sciences 26, no. 19: 9659. https://doi.org/10.3390/ijms26199659

APA Style

Ismail Mendi, B., Hirani, R., Sayegh, A., Hassan, M., Fleshner, L., Farabi, B., Atak, M. F., & Safai, B. (2025). Utilization of Stem Cells in Medicine: A Narrative Review. International Journal of Molecular Sciences, 26(19), 9659. https://doi.org/10.3390/ijms26199659

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