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Correction to Int. J. Mol. Sci. 2022, 23(21), 13144.
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Correction

Correction: Antonuccio et al. Involvement of Hypoxia-Inducible Factor 1-α in Experimental Testicular Ischemia and Reperfusion: Effects of Polydeoxyribonucleotide and Selenium. Int. J. Mol. Sci. 2022, 23, 13144

by
Pietro Antonuccio
1,
Giovanni Pallio
2,
Herbert Ryan Marini
2,
Natasha Irrera
2,
Carmelo Romeo
1,
Domenico Puzzolo
3,
Jose Freni
3,
Giuseppe Santoro
3,
Igor Pirrotta
2,
Francesco Squadrito
2,
Letteria Minutoli
2,* and
Antonio Micali
1
1
Department of Human Adult and Childhood Pathology, University of Messina, 98125 Messina, Italy
2
Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy
3
Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(17), 8636; https://doi.org/10.3390/ijms26178636
Submission received: 7 August 2025 / Accepted: 21 August 2025 / Published: 5 September 2025
(This article belongs to the Section Bioactives and Nutraceuticals)
Browse Figure
Versions Notes
In the original publication [1], there was a mistake in Figure 3, Panel A, in which the authors presented a picture very similar to another proposed in a paper published at a different time [2]. The corrected Figure 3 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

References

  1. Antonuccio, P.; Pallio, G.; Marini, H.R.; Irrera, N.; Romeo, C.; Puzzolo, D.; Freni, J.; Santoro, G.; Pirrotta, I.; Squadrito, F.; et al. Involvement of Hypoxia-Inducible Factor 1-α in Experimental Testicular Ischemia and Reperfusion: Effects of Polydeoxyribonucleotide and Selenium. Int. J. Mol. Sci. 2022, 23, 13144. [Google Scholar] [CrossRef] [PubMed]
  2. Antonuccio, P.; Micali, A.G.; Romeo, C.; Freni, J.; Vermiglio, G.; Puzzolo, D.; Squadrito, F.; Irrera, N.; Marini, H.R.; Rana, R.A.; et al. NLRP3 Inflammasome: A New Pharmacological Target for Reducing Testicular Damage Associated with Varicocele. Int. J. Mol. Sci. 2021, 22, 1319. [Google Scholar] [CrossRef] [PubMed]
Ijms 26 08636 g003
Figure 3. Assessment of apoptosis in the different groups of rat testes with TUNEL stain. (A) In the testes of all sham rats, no TUNEL-positive cells were present. (B,C) Many TUNEL-positive cells (arrow) were seen in the wall of the seminiferous tubules of I/R + vehicle rats and in CL testes of the same group. (D,E) In I/R + PDRN alone-treated rats and in the CL testes of the same group, TUNEL-positive cells (arrow) were decreased when compared with I/R rats. (F,G) In I/R + Se-treated rats and in CL testes of the same group, only isolated TUNEL-positive cells were present. (H,I) In I/R rats treated with the association PDRN + Se, in both operated and CL testes, only rarely isolated TUNEL-positive germ cells were observed. (J) Tubules with apoptotic cells (TWAC) (expressed in %) in the different groups of rats. (K) Apoptotic index values (apoptotic cells/tubule) in the different groups of rats. * p ≤ 0.05 versus sham group; § p ≤ 0.05 versus I/R rats (scale bar: (A,D–I) = 100 μm; (B,C) = 50 μm).
Figure 3. Assessment of apoptosis in the different groups of rat testes with TUNEL stain. (A) In the testes of all sham rats, no TUNEL-positive cells were present. (B,C) Many TUNEL-positive cells (arrow) were seen in the wall of the seminiferous tubules of I/R + vehicle rats and in CL testes of the same group. (D,E) In I/R + PDRN alone-treated rats and in the CL testes of the same group, TUNEL-positive cells (arrow) were decreased when compared with I/R rats. (F,G) In I/R + Se-treated rats and in CL testes of the same group, only isolated TUNEL-positive cells were present. (H,I) In I/R rats treated with the association PDRN + Se, in both operated and CL testes, only rarely isolated TUNEL-positive germ cells were observed. (J) Tubules with apoptotic cells (TWAC) (expressed in %) in the different groups of rats. (K) Apoptotic index values (apoptotic cells/tubule) in the different groups of rats. * p ≤ 0.05 versus sham group; § p ≤ 0.05 versus I/R rats (scale bar: (A,D–I) = 100 μm; (B,C) = 50 μm).
Ijms 26 08636 g003
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MDPI and ACS Style

Antonuccio, P.; Pallio, G.; Marini, H.R.; Irrera, N.; Romeo, C.; Puzzolo, D.; Freni, J.; Santoro, G.; Pirrotta, I.; Squadrito, F.; et al. Correction: Antonuccio et al. Involvement of Hypoxia-Inducible Factor 1-α in Experimental Testicular Ischemia and Reperfusion: Effects of Polydeoxyribonucleotide and Selenium. Int. J. Mol. Sci. 2022, 23, 13144. Int. J. Mol. Sci. 2025, 26, 8636. https://doi.org/10.3390/ijms26178636

AMA Style

Antonuccio P, Pallio G, Marini HR, Irrera N, Romeo C, Puzzolo D, Freni J, Santoro G, Pirrotta I, Squadrito F, et al. Correction: Antonuccio et al. Involvement of Hypoxia-Inducible Factor 1-α in Experimental Testicular Ischemia and Reperfusion: Effects of Polydeoxyribonucleotide and Selenium. Int. J. Mol. Sci. 2022, 23, 13144. International Journal of Molecular Sciences. 2025; 26(17):8636. https://doi.org/10.3390/ijms26178636

Chicago/Turabian Style

Antonuccio, Pietro, Giovanni Pallio, Herbert Ryan Marini, Natasha Irrera, Carmelo Romeo, Domenico Puzzolo, Jose Freni, Giuseppe Santoro, Igor Pirrotta, Francesco Squadrito, and et al. 2025. "Correction: Antonuccio et al. Involvement of Hypoxia-Inducible Factor 1-α in Experimental Testicular Ischemia and Reperfusion: Effects of Polydeoxyribonucleotide and Selenium. Int. J. Mol. Sci. 2022, 23, 13144" International Journal of Molecular Sciences 26, no. 17: 8636. https://doi.org/10.3390/ijms26178636

APA Style

Antonuccio, P., Pallio, G., Marini, H. R., Irrera, N., Romeo, C., Puzzolo, D., Freni, J., Santoro, G., Pirrotta, I., Squadrito, F., Minutoli, L., & Micali, A. (2025). Correction: Antonuccio et al. Involvement of Hypoxia-Inducible Factor 1-α in Experimental Testicular Ischemia and Reperfusion: Effects of Polydeoxyribonucleotide and Selenium. Int. J. Mol. Sci. 2022, 23, 13144. International Journal of Molecular Sciences, 26(17), 8636. https://doi.org/10.3390/ijms26178636

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