Next Article in Journal
Idiopathic Inflammatory Myopathy—Molecular Mechanisms Underlying Its Pathogenesis and Physical Therapy Effects
Previous Article in Journal
Functionalized Indolizines as Potential Anticancer Agents: Synthetic, Biological and In Silico Investigations
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 26
Issue 17
10.3390/ijms26178367
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Association of Circulating miRNAs from the C19MC Cluster and IGF System with Macrosomia in Women with Gestational Diabetes Mellitus

by
Magalhi Guadalupe Robledo-Clemente
1,
Juan Carlos Silva Godínez
2,3,4,
Mary Flor Díaz-Velázquez
1,
Edgar Mendoza Reyes
1,
José Damián Gómez Archilla
1,
Lucia Daniela García Montes
1,
Mauricio Ramiro Cortez Chávez
1,
María Isabel Peña-Cano
5 and
Renata Saucedo
6,*
1
Unidad Médica de Alta Especialidad, Hospital de Gineco-Obstetricia No. 3 “Dr. Víctor Manuel Espinosa de los Reyes Sánchez”, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, México City 02990, México
2
PPCR Program, ECPE Department, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
3
Escuela Nacional Colegio de Ciencias y Humanidades, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
4
Hospital General “Dra. Matilde Petra Montoya Lafragua”, Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado, México City 13273, México
5
Hospital de Gineco-Obstetricia 221, Instituto Mexicano del Seguro Social, Toluca 50150, México
6
Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades “Dr. Bernardo Sepúlveda Gutiérrez”, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México City 06720, México
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(17), 8367; https://doi.org/10.3390/ijms26178367 (registering DOI)
Submission received: 13 June 2025 / Revised: 3 August 2025 / Accepted: 12 August 2025 / Published: 28 August 2025
(This article belongs to the Section Molecular Genetics and Genomics)
Review Reports Versions Notes

Abstract

Gestational diabetes mellitus (GDM) increases the risk of fetal overgrowth and macrosomia, yet the molecular mechanisms remain unclear. Emerging evidence implicates primate-specific placental microRNAs (miRNAs) from the C19MC cluster in modulating fetal growth via the insulin-like growth factor (IGF) axis. This study aimed to investigate the expression of circulating C19MC miRNAs in GDM pregnancies and their association with IGF axis biomarkers and birthweight outcomes. In this cross-sectional study, 158 pregnant women were stratified into normoglycemic pregnancies (n = 52), GDM with normal birthweight (n = 56), and GDM with large-for-gestational-age (LGA) newborns (n = 50). Plasma levels of 19 C19MC miRNAs and IGF-related proteins were measured. Associations between miRNAs, IGF axis components, and birthweight were analyzed using linear regression and correlation models adjusted for relevant covariates. Several miRNAs, including miR-516a-5p, miR-518d-3p, miR-521, and miR-525-3p, were differentially expressed in GDM, particularly in LGA cases. Strong correlations were observed, such as that of miR-516a-5p with IGFBP-5 (r = 0.705; p < 0.001). Inverse associations with birthweight were found for miR-519b-3p, miR-518d-5p, and miR-520a-5p. Circulating C19MC miRNAs are dysregulated in GDM and correlate with IGF signaling and fetal growth, supporting their potential as early biomarkers for macrosomia risk in GDM.
Keywords: gestational diabetes mellitus (GDM); fetal macrosomia; C19MC microRNAs; insulin-like growth factor (IGF) system; IGF-binding proteins (IGFBPs); placental biomarkers; epigenetic regulation gestational diabetes mellitus (GDM); fetal macrosomia; C19MC microRNAs; insulin-like growth factor (IGF) system; IGF-binding proteins (IGFBPs); placental biomarkers; epigenetic regulation

Share and Cite

MDPI and ACS Style

Robledo-Clemente, M.G.; Silva Godínez, J.C.; Díaz-Velázquez, M.F.; Mendoza Reyes, E.; Gómez Archilla, J.D.; García Montes, L.D.; Cortez Chávez, M.R.; Peña-Cano, M.I.; Saucedo, R. Association of Circulating miRNAs from the C19MC Cluster and IGF System with Macrosomia in Women with Gestational Diabetes Mellitus. Int. J. Mol. Sci. 2025, 26, 8367. https://doi.org/10.3390/ijms26178367

AMA Style

Robledo-Clemente MG, Silva Godínez JC, Díaz-Velázquez MF, Mendoza Reyes E, Gómez Archilla JD, García Montes LD, Cortez Chávez MR, Peña-Cano MI, Saucedo R. Association of Circulating miRNAs from the C19MC Cluster and IGF System with Macrosomia in Women with Gestational Diabetes Mellitus. International Journal of Molecular Sciences. 2025; 26(17):8367. https://doi.org/10.3390/ijms26178367

Chicago/Turabian Style

Robledo-Clemente, Magalhi Guadalupe, Juan Carlos Silva Godínez, Mary Flor Díaz-Velázquez, Edgar Mendoza Reyes, José Damián Gómez Archilla, Lucia Daniela García Montes, Mauricio Ramiro Cortez Chávez, María Isabel Peña-Cano, and Renata Saucedo. 2025. "Association of Circulating miRNAs from the C19MC Cluster and IGF System with Macrosomia in Women with Gestational Diabetes Mellitus" International Journal of Molecular Sciences 26, no. 17: 8367. https://doi.org/10.3390/ijms26178367

APA Style

Robledo-Clemente, M. G., Silva Godínez, J. C., Díaz-Velázquez, M. F., Mendoza Reyes, E., Gómez Archilla, J. D., García Montes, L. D., Cortez Chávez, M. R., Peña-Cano, M. I., & Saucedo, R. (2025). Association of Circulating miRNAs from the C19MC Cluster and IGF System with Macrosomia in Women with Gestational Diabetes Mellitus. International Journal of Molecular Sciences, 26(17), 8367. https://doi.org/10.3390/ijms26178367

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop