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Article

Associations Between Genetic Variants in MCT2 (rs3763980, rs995343, rs3763979) and MCT4 (rs11323780) with Blood Lactate Kinetics Before and After Supramaximal Exercise

by
Ewelina Maculewicz
1,2,
Aleksandra Bojarczuk
3,*,
Andrzej Mastalerz
1,
Monika Johne
1,
Anna Mróz
1,
Aleksandra Garbacz
4 and
Petr Stastny
5
1
Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-968 Warsaw, Poland
2
Department of Laboratory Diagnostics, Military Institute of Aviation Medicine, 01-755 Warsaw, Poland
3
Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
4
Faculty of Animal Genetics and Conservation, Warsaw University of Life Sciences, 02-787 Warsaw, Poland
5
Faculty of Physical Education and Sport, Charles University, 162-52 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(16), 7865; https://doi.org/10.3390/ijms26167865
Submission received: 20 June 2025 / Revised: 6 August 2025 / Accepted: 8 August 2025 / Published: 14 August 2025
(This article belongs to the Section Molecular Biology)
Versions Notes

Abstract

Despite progress in understanding the role of monocarboxylate transporters (MCTs) in lactate (LA) accumulation and removal, it remains unclear whether MCT2 and MCT4 variants enhance LA utilization. This study assessed associations between MCT2 (rs3763980, rs995343, rs3763979) and MCT4 (rs11323780) polymorphisms and LA concentration. A total of 337 male athletes from the Czech Republic and Poland, divided into elite, sub-elite, and physically active individuals, completed two all-out Wingate tests. Before these tests, DNA was collected and analyzed for single-nucleotide polymorphisms (SNPs). LA concentrations were measured before and after the tests. MCT2 rs995343 showed the broadest associations. It was significantly associated with resting LA (LArest) in the overall cohort (codominant: false discovery rate (FDR)-adjusted p = 0.04; dominant: FDR-adjusted p = 0.03) and with peak LA concentration (LAmax), accumulation (ACC), and clearance (DCC) in the physically active group (all models: FDR-adjusted p = 0.02–0.04). MCT2 rs3763980 was associated with LArest in the overall group (codominant and recessive: FDR-adjusted p = 0.04). MCT2 rs3763979 was associated with LArest (FDR-adjusted p = 0.009–0.003) and LA30′ (FDR-adjusted p = 0.003–0.04) in the overall and physically active cohorts. MCT4 rs11323780 was associated with LArest in elite athletes (recessive: FDR-adjusted p = 0.03) and with ACC in the physically active group (codominant and recessive: FDR-adjusted p = 0.03). These findings indicate that MCT polymorphisms contribute to variability in LA metabolism, influencing anaerobic performance and recovery.
Keywords: genotype; genetic variants; lactate kinetics; athletic training; sprint; elite athletes; sub-elite athletes; physical activity genotype; genetic variants; lactate kinetics; athletic training; sprint; elite athletes; sub-elite athletes; physical activity

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MDPI and ACS Style

Maculewicz, E.; Bojarczuk, A.; Mastalerz, A.; Johne, M.; Mróz, A.; Garbacz, A.; Stastny, P. Associations Between Genetic Variants in MCT2 (rs3763980, rs995343, rs3763979) and MCT4 (rs11323780) with Blood Lactate Kinetics Before and After Supramaximal Exercise. Int. J. Mol. Sci. 2025, 26, 7865. https://doi.org/10.3390/ijms26167865

AMA Style

Maculewicz E, Bojarczuk A, Mastalerz A, Johne M, Mróz A, Garbacz A, Stastny P. Associations Between Genetic Variants in MCT2 (rs3763980, rs995343, rs3763979) and MCT4 (rs11323780) with Blood Lactate Kinetics Before and After Supramaximal Exercise. International Journal of Molecular Sciences. 2025; 26(16):7865. https://doi.org/10.3390/ijms26167865

Chicago/Turabian Style

Maculewicz, Ewelina, Aleksandra Bojarczuk, Andrzej Mastalerz, Monika Johne, Anna Mróz, Aleksandra Garbacz, and Petr Stastny. 2025. "Associations Between Genetic Variants in MCT2 (rs3763980, rs995343, rs3763979) and MCT4 (rs11323780) with Blood Lactate Kinetics Before and After Supramaximal Exercise" International Journal of Molecular Sciences 26, no. 16: 7865. https://doi.org/10.3390/ijms26167865

APA Style

Maculewicz, E., Bojarczuk, A., Mastalerz, A., Johne, M., Mróz, A., Garbacz, A., & Stastny, P. (2025). Associations Between Genetic Variants in MCT2 (rs3763980, rs995343, rs3763979) and MCT4 (rs11323780) with Blood Lactate Kinetics Before and After Supramaximal Exercise. International Journal of Molecular Sciences, 26(16), 7865. https://doi.org/10.3390/ijms26167865

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