Next Article in Journal
Epigenomics Nutritional Insights of Crocus sativus L.: Computational Analysis of Bioactive Molecules Targeting DNA Methyltransferases and Histone Deacetylases
Previous Article in Journal
Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise
Previous Article in Special Issue
What a Modern Physician Should Know About microRNAs in the Diagnosis and Treatment of Diabetic Kidney Disease
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 26
Issue 15
10.3390/ijms26157574
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Diabetes and Sarcopenia: Metabolomic Signature of Pathogenic Pathways and Targeted Therapies

by
Anamaria Andreea Danciu
1,2,
Cornelia Bala
2,3,*,
Georgeta Inceu
2,3,
Camelia Larisa Vonica
3,
Adriana Rusu
2,3,
Gabriela Roman
2,3 and
Dana Mihaela Ciobanu
2,3
1
Ph.D. School, “Iuliu Haṭieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
2
Diabetes Center, Emergency Clinical County Hospital Cluj, 400006 Cluj-Napoca, Romania
3
Department of Diabetes and Nutrition Diseases, “Iuliu Haṭieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(15), 7574; https://doi.org/10.3390/ijms26157574 (registering DOI)
Submission received: 16 June 2025 / Revised: 18 July 2025 / Accepted: 4 August 2025 / Published: 5 August 2025
(This article belongs to the Special Issue Molecular Advances on Insulin Resistance and Metabolic Dysfunction, 2nd Edition)
Versions Notes

Abstract

Diabetes mellites (DM) is a chronic disease with increasing prevalence worldwide and multiple health implications. Among them, sarcopenia is a metabolic disorder characterized by loss of muscle mass and function. The two age-related diseases, DM and sarcopenia, share underlying pathophysiological pathways. This narrative literature review aims to provide an overview of the existing evidence on metabolomic studies evaluating DM associated with sarcopenia. Advancements in targeted and untargeted metabolomics techniques could provide better insight into the pathogenesis of sarcopenia in DM and describe their entangled and fluctuating interrelationship. Recent evidence showed that sarcopenia in DM induced significant changes in protein, lipid, carbohydrate, and in energy metabolisms in humans, animal models of DM, and cell cultures. Newer metabolites were reported, known metabolites were also found significantly modified, while few amino acids and lipids displayed a dual behavior. In addition, several therapeutic approaches proved to be promising interventions for slowing the progression of sarcopenia in DM, including physical activity, newer antihyperglycemic classes, D-pinitol, and genetic USP21 ablation, although none of them were yet validated for clinical use. Conversely, ceramides had a negative impact. Further research is needed to confirm the utility of these findings and to provide potential metabolomic biomarkers that might be relevant for the pathogenesis and treatment of sarcopenia in DM.
Keywords: metabolomics; diabetes mellitus; sarcopenia; therapeutic approach; narrative review metabolomics; diabetes mellitus; sarcopenia; therapeutic approach; narrative review

Share and Cite

MDPI and ACS Style

Danciu, A.A.; Bala, C.; Inceu, G.; Vonica, C.L.; Rusu, A.; Roman, G.; Ciobanu, D.M. Diabetes and Sarcopenia: Metabolomic Signature of Pathogenic Pathways and Targeted Therapies. Int. J. Mol. Sci. 2025, 26, 7574. https://doi.org/10.3390/ijms26157574

AMA Style

Danciu AA, Bala C, Inceu G, Vonica CL, Rusu A, Roman G, Ciobanu DM. Diabetes and Sarcopenia: Metabolomic Signature of Pathogenic Pathways and Targeted Therapies. International Journal of Molecular Sciences. 2025; 26(15):7574. https://doi.org/10.3390/ijms26157574

Chicago/Turabian Style

Danciu, Anamaria Andreea, Cornelia Bala, Georgeta Inceu, Camelia Larisa Vonica, Adriana Rusu, Gabriela Roman, and Dana Mihaela Ciobanu. 2025. "Diabetes and Sarcopenia: Metabolomic Signature of Pathogenic Pathways and Targeted Therapies" International Journal of Molecular Sciences 26, no. 15: 7574. https://doi.org/10.3390/ijms26157574

APA Style

Danciu, A. A., Bala, C., Inceu, G., Vonica, C. L., Rusu, A., Roman, G., & Ciobanu, D. M. (2025). Diabetes and Sarcopenia: Metabolomic Signature of Pathogenic Pathways and Targeted Therapies. International Journal of Molecular Sciences, 26(15), 7574. https://doi.org/10.3390/ijms26157574

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Article metric data becomes available approximately 24 hours after publication online.
Back to TopTop