Next Article in Journal
Luminescent Properties and Cytotoxic Activity of 2-phenylbenzoxazole Fluorosulfate Derivatives
Previous Article in Journal
Development and Future Prospects of Bamboo Gene Science
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 26
Issue 15
10.3390/ijms26157260
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Assessment of Eotaxin Concentration in Children with Chronic Kidney Disease

by
Marta Badeńska
1,
Andrzej Badeński
1,*,
Elżbieta Świętochowska
2,
Artur Janek
3,
Karolina Marczak
4,
Aleksandra Gliwińska
1 and
Maria Szczepańska
1
1
Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13/15, 41-800 Zabrze, Poland
2
Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Katowice, Poland
3
Clinical Department of Pediatrics, Specialist Hospital No. 2 in Bytom, ul. Batorego 15, 41-902 Bytom, Poland
4
Department of Pediatric Nephrology with Dialysis Division for Children, Public Clinical Hospital No. 1 in Zabrze, 41-800 Zabrze, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(15), 7260; https://doi.org/10.3390/ijms26157260 (registering DOI)
Submission received: 26 June 2025 / Revised: 23 July 2025 / Accepted: 25 July 2025 / Published: 27 July 2025
(This article belongs to the Special Issue Molecular Pathology and Next-Generation Biomarkers in Nephrology)
Review Reports Versions Notes

Abstract

Chronic kidney disease (CKD) is a progressive condition which still leads to significant morbidity and mortality among patients at all ages. Its proper management should be focused on slowing down the disease sequelae, as well as establishing an early diagnosis and treatment of its complications. Eotaxin is a potent, selective eosinophil chemoattractant, which is reported to have an impact on various kidney diseases. Nevertheless, data regarding the potential correlation between eotaxin and CKD in a pediatric population is still scarce. This study aims to assess the concentration of eotaxin in children with CKD and evaluate potential correlations with selected biochemical markers and disease occurrence. Both serum and urine eotaxin concentrations were markedly higher in children with CKD compared to healthy controls. Moreover, Receiver Operating Characteristic (ROC) curves have shown that serum eotaxin and urine eotaxin levels demonstrated high sensitivity and high specificity for the allocation of patients to the study and control groups. The authors advanced a thesis that eotaxin might serve as a marker of CKD occurrence in a pediatric population. Such a research design is innovative, since it has not been analyzed in the literature yet. However, further studies are required.
Keywords: chronic kidney disease; eotaxin; eosinophil chemotactic factor; children chronic kidney disease; eotaxin; eosinophil chemotactic factor; children

Share and Cite

MDPI and ACS Style

Badeńska, M.; Badeński, A.; Świętochowska, E.; Janek, A.; Marczak, K.; Gliwińska, A.; Szczepańska, M. Assessment of Eotaxin Concentration in Children with Chronic Kidney Disease. Int. J. Mol. Sci. 2025, 26, 7260. https://doi.org/10.3390/ijms26157260

AMA Style

Badeńska M, Badeński A, Świętochowska E, Janek A, Marczak K, Gliwińska A, Szczepańska M. Assessment of Eotaxin Concentration in Children with Chronic Kidney Disease. International Journal of Molecular Sciences. 2025; 26(15):7260. https://doi.org/10.3390/ijms26157260

Chicago/Turabian Style

Badeńska, Marta, Andrzej Badeński, Elżbieta Świętochowska, Artur Janek, Karolina Marczak, Aleksandra Gliwińska, and Maria Szczepańska. 2025. "Assessment of Eotaxin Concentration in Children with Chronic Kidney Disease" International Journal of Molecular Sciences 26, no. 15: 7260. https://doi.org/10.3390/ijms26157260

APA Style

Badeńska, M., Badeński, A., Świętochowska, E., Janek, A., Marczak, K., Gliwińska, A., & Szczepańska, M. (2025). Assessment of Eotaxin Concentration in Children with Chronic Kidney Disease. International Journal of Molecular Sciences, 26(15), 7260. https://doi.org/10.3390/ijms26157260

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Article metric data becomes available approximately 24 hours after publication online.
Back to TopTop