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Article

Can α-Mangostin and Photodynamic Therapy Support Ciprofloxacin in the Inactivation of Uropathogenic Escherichia coli and Staphylococcus aureus Strains?

by
Dorota Wojnicz
1,
Kamila Korzekwa
2,
Mateusz Guźniczak
3,
Maciej Wernecki
2,
Agnieszka Ulatowska-Jarża
3,
Igor Buzalewicz
3 and
Dorota Tichaczek-Goska
1,*
1
Department of Biology and Medical Parasitology, Faculty of Medicine, Wrocław Medical University, Mikulicza-Radeckiego 9, 50-345 Wroclaw, Poland
2
Department of Microbiology, Faculty of Biological Sciences, University of Wrocław, Przybyszewskiego 63, 51-148 Wroclaw, Poland
3
BioQuanty Group, Department of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology, 27 Wybrzeże S. Wyspiańskiego St., 50-370 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(1), 76; https://doi.org/10.3390/ijms26010076
Submission received: 30 November 2024 / Revised: 21 December 2024 / Accepted: 23 December 2024 / Published: 25 December 2024
(This article belongs to the Special Issue Molecular Aspects of Photodynamic Therapy)
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Abstract

Multidrug-resistant bacteria represent a significant challenge in the treatment of bacterial infections, often leading to therapeutic failures. This issue underlines the need to develop strategies that improve the efficacy of conventional antibiotic therapies. In this study, we aimed to assess whether a plant-derived compound, α-mangostin, and photodynamic therapy (PDT) could enhance the antibacterial activity of ciprofloxacin against uropathogenic strains of Escherichia coli and Staphylococcus aureus. Using nanopore sequencing technology, we confirmed that the clinical strains tested were classified as multidrug-resistant. Digital holotomography (DHT) was used to examine α-mangostin-induced changes in the bacterial cells’ penetration by a photosensitizer. A scanning confocal fluorescence microscope was used to visualize photosensitizer penetration into bacterial cells and validate DHT results. A synergistic effect between α-mangostin and ciprofloxacin was observed exclusively in S. aureus strains, while no enhancement of ciprofloxacin’s antibacterial activity was detected in E. coli strains when combined with α-mangostin. Notably, photodynamic therapy significantly potentiated the antibacterial effects of ciprofloxacin and its combination with α-mangostin compared to untreated controls. In addition, morphological changes were observed in bacterial cells exposed to these antimicrobials. In conclusion, our findings suggest that α-mangostin and PDT may serve as valuable adjuncts to ciprofloxacin, improving the eradication of uropathogens.
Keywords: ciprofloxacin; α-mangostin; multidrug-resistant bacteria; PDT; UTI ciprofloxacin; α-mangostin; multidrug-resistant bacteria; PDT; UTI

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MDPI and ACS Style

Wojnicz, D.; Korzekwa, K.; Guźniczak, M.; Wernecki, M.; Ulatowska-Jarża, A.; Buzalewicz, I.; Tichaczek-Goska, D. Can α-Mangostin and Photodynamic Therapy Support Ciprofloxacin in the Inactivation of Uropathogenic Escherichia coli and Staphylococcus aureus Strains? Int. J. Mol. Sci. 2025, 26, 76. https://doi.org/10.3390/ijms26010076

AMA Style

Wojnicz D, Korzekwa K, Guźniczak M, Wernecki M, Ulatowska-Jarża A, Buzalewicz I, Tichaczek-Goska D. Can α-Mangostin and Photodynamic Therapy Support Ciprofloxacin in the Inactivation of Uropathogenic Escherichia coli and Staphylococcus aureus Strains? International Journal of Molecular Sciences. 2025; 26(1):76. https://doi.org/10.3390/ijms26010076

Chicago/Turabian Style

Wojnicz, Dorota, Kamila Korzekwa, Mateusz Guźniczak, Maciej Wernecki, Agnieszka Ulatowska-Jarża, Igor Buzalewicz, and Dorota Tichaczek-Goska. 2025. "Can α-Mangostin and Photodynamic Therapy Support Ciprofloxacin in the Inactivation of Uropathogenic Escherichia coli and Staphylococcus aureus Strains?" International Journal of Molecular Sciences 26, no. 1: 76. https://doi.org/10.3390/ijms26010076

APA Style

Wojnicz, D., Korzekwa, K., Guźniczak, M., Wernecki, M., Ulatowska-Jarża, A., Buzalewicz, I., & Tichaczek-Goska, D. (2025). Can α-Mangostin and Photodynamic Therapy Support Ciprofloxacin in the Inactivation of Uropathogenic Escherichia coli and Staphylococcus aureus Strains? International Journal of Molecular Sciences, 26(1), 76. https://doi.org/10.3390/ijms26010076

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