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Article

Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study

by
Marlene Fabiola Escobedo-Monge
1,*,
Marianela Marcos-Temprano
2,
Joaquín Parodi-Román
3,
María Antonieta Escobedo-Monge
4,
Carmen Alonso-Vicente
5,
María Carmen Torres-Hinojal
1 and
José Manuel Marugán-Miguelsanz
5
1
Faculty of Medicine, University of Valladolid, Avenida Ramón y Cajal, 7, 47005 Valladolid, Spain
2
Castilla y León Cystic Fibrosis Unit, University Clinical Hospital of Valladolid, Avenida Ramón y Cajal, 3, 47005 Valladolid, Spain
3
Science Faculty, University of Cadiz, Paseo de Carlos III, 28, 11003 Cádiz, Spain
4
Department of Chemistry, Science Faculty, University of Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain
5
Department of Pediatrics of the Faculty of Medicine, University of Valladolid; Section of Gastroenterology and Pediatric Nutrition, University Clinical Hospital of Valladolid, Avenida Ramón y Cajal, 7, 47005 Valladolid, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(3), 1900; https://doi.org/10.3390/ijms25031900
Submission received: 27 November 2023 / Revised: 3 January 2024 / Accepted: 27 January 2024 / Published: 5 February 2024
(This article belongs to the Special Issue Precision Medicine Cystic Fibrosis)
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Abstract

Cystic fibrosis (CF) is a monogenic disease with different types of mutations that mainly affect the respiratory-digestive system. Calcium (Ca), phosphorus (P), and vitamin D (Vit-D) are essential nutrients for maintaining adequate growth and development, as well as key components in crucial metabolic pathways. Proper diagnosis, treatment, and response are decisive components of precision medicine. Therefore, we conducted a cross-sectional study to evaluate Ca, P, and Vit-D levels along with health and nutritional indicators, regarding their non-skeletal functions, in a series of CF patients. Anthropometric and clinical evaluation, biochemical analysis, dietary survey, and respiratory and pancreatic status were performed. Even though the results showed that all patients had normal dietary and serum Ca levels, 47% of patients had deficient Vit-D intake, 53% of patients had hypovitaminosis D, 35% had insufficient Vit-D levels, 18% had hypophosphatemia, 76% had elevated alkaline phosphate levels, 29% had hypercalciuria, and 65% had hyperphosphaturia. There were no significant differences between homozygous and compound heterozygous patients. Ca, P, and Vit-D levels were associated with body mass index; body composition; physical activity; diet; growth hormones; and the immune, liver, and kidney systems. We suggest a periodically evaluation of Ca and P losses.
Keywords: nutritional status; calcium/phosphorus ratio; phosphatase alkaline; physical activity nutritional status; calcium/phosphorus ratio; phosphatase alkaline; physical activity

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MDPI and ACS Style

Escobedo-Monge, M.F.; Marcos-Temprano, M.; Parodi-Román, J.; Escobedo-Monge, M.A.; Alonso-Vicente, C.; Torres-Hinojal, M.C.; Marugán-Miguelsanz, J.M. Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study. Int. J. Mol. Sci. 2024, 25, 1900. https://doi.org/10.3390/ijms25031900

AMA Style

Escobedo-Monge MF, Marcos-Temprano M, Parodi-Román J, Escobedo-Monge MA, Alonso-Vicente C, Torres-Hinojal MC, Marugán-Miguelsanz JM. Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study. International Journal of Molecular Sciences. 2024; 25(3):1900. https://doi.org/10.3390/ijms25031900

Chicago/Turabian Style

Escobedo-Monge, Marlene Fabiola, Marianela Marcos-Temprano, Joaquín Parodi-Román, María Antonieta Escobedo-Monge, Carmen Alonso-Vicente, María Carmen Torres-Hinojal, and José Manuel Marugán-Miguelsanz. 2024. "Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study" International Journal of Molecular Sciences 25, no. 3: 1900. https://doi.org/10.3390/ijms25031900

APA Style

Escobedo-Monge, M. F., Marcos-Temprano, M., Parodi-Román, J., Escobedo-Monge, M. A., Alonso-Vicente, C., Torres-Hinojal, M. C., & Marugán-Miguelsanz, J. M. (2024). Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study. International Journal of Molecular Sciences, 25(3), 1900. https://doi.org/10.3390/ijms25031900

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