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Volume 25
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10.3390/ijms25031642
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Article

Neural Stem Cells Transplanted into Rhesus Monkey Cortical Traumatic Brain Injury Can Survive and Differentiate into Neurons

by
Shuyi Liu
1,2,†,
Liping Shi
1,2,†,
Tianzhuang Huang
1,2,
Yuyi Luo
1,2,
Yongchang Chen
1,2,*,
Shangang Li
1,2 and
Zhengbo Wang
1,2,*
1
State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China
2
Yunnan Key Laboratory of Primate Biomedical Research, Kunming 650500, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(3), 1642; https://doi.org/10.3390/ijms25031642
Submission received: 13 December 2023 / Revised: 19 January 2024 / Accepted: 23 January 2024 / Published: 29 January 2024
(This article belongs to the Section Molecular Neurobiology)
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Abstract

Cortical traumatic brain injury (TBI) is a major cause of cognitive impairment accompanied by motor and behavioral deficits, and there is no effective treatment strategy in the clinic. Cell transplantation is a promising therapeutic strategy, and it is necessary to verify the survival and differentiation of cells after transplantation in large animal models like rhesus monkeys. In this study, we transplanted neural stem cells (NSCs) and simultaneously injected basic fibroblast growth factor/epidermal growth factor (bFGF/EGF) into the cortex (visual and sensory cortices) of rhesus monkeys with superficial TBI. The results showed that the transplanted NSCs did not enter the cerebrospinal fluid (CSF) and were confined to the transplantation site for at least one year. The transplanted NSCs differentiated into mature neurons that formed synaptic connections with host neurons, but glial scar formation between the graft and the host tissue did not occur. This study is the first to explore the repairing effect of transplanting NSCs into the superficial cerebral cortex of rhesus monkeys after TBI, and the results show the ability of NSCs to survive long-term and differentiate into neurons, demonstrating the potential of NSC transplantation for cortical TBI.
Keywords: superficial cerebral cortex; synaptic connections; long-term beneficial; glial scar formation superficial cerebral cortex; synaptic connections; long-term beneficial; glial scar formation
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MDPI and ACS Style

Liu, S.; Shi, L.; Huang, T.; Luo, Y.; Chen, Y.; Li, S.; Wang, Z. Neural Stem Cells Transplanted into Rhesus Monkey Cortical Traumatic Brain Injury Can Survive and Differentiate into Neurons. Int. J. Mol. Sci. 2024, 25, 1642. https://doi.org/10.3390/ijms25031642

AMA Style

Liu S, Shi L, Huang T, Luo Y, Chen Y, Li S, Wang Z. Neural Stem Cells Transplanted into Rhesus Monkey Cortical Traumatic Brain Injury Can Survive and Differentiate into Neurons. International Journal of Molecular Sciences. 2024; 25(3):1642. https://doi.org/10.3390/ijms25031642

Chicago/Turabian Style

Liu, Shuyi, Liping Shi, Tianzhuang Huang, Yuyi Luo, Yongchang Chen, Shangang Li, and Zhengbo Wang. 2024. "Neural Stem Cells Transplanted into Rhesus Monkey Cortical Traumatic Brain Injury Can Survive and Differentiate into Neurons" International Journal of Molecular Sciences 25, no. 3: 1642. https://doi.org/10.3390/ijms25031642

APA Style

Liu, S., Shi, L., Huang, T., Luo, Y., Chen, Y., Li, S., & Wang, Z. (2024). Neural Stem Cells Transplanted into Rhesus Monkey Cortical Traumatic Brain Injury Can Survive and Differentiate into Neurons. International Journal of Molecular Sciences, 25(3), 1642. https://doi.org/10.3390/ijms25031642

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