Review Reports

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

please see my evaluation in the attached PDF file

Comments for author File: Comments.pdf

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

Comments and Suggestions for Authors

I found this article to be quite intriguing. While my expertise is primarily in lipid analysis via LC-MS, I believe the biological aspects are sound. To further enhance the manuscript, I suggest the following minor revisions:

The high standard deviation in MMC results warrants further discussion in the text. Why such a higher variability?

Include in the supplementary material a chromatogram of analysed samples  and/or a table with monitored transitions and retention times.

 Please adopt the current lipidomics nomenclature standards (see: 10.1194/jlr.S120001025)

Correct the labeling errors in Figure 3 and 4.

Consider using "Quantification via LC-MS" or simply "Quantification" instead of "mass spectrometric quantification".

Replace "Fig." with "Figure" in the discussion section.

Author Response

Please see the attachment

Author Response File: Author Response.docx