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Volume 25
Issue 22
10.3390/ijms252212175
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Article
Peer-Review Record

Acid Sphingomyelinase Activation and ROS Generation Potentiate Antiproliferative Effects of Mitomycin in HCC

Int. J. Mol. Sci. 2024, 25(22), 12175; https://doi.org/10.3390/ijms252212175
by Sirkka Buitkamp 1,2, Stephanie Schwalm 1, Katja Jakobi 1,3, Nerea Ferreiros 4,5, Christin Wünsche 1,6, Stefan Zeuzem 7, Erich Gulbins 8, Christoph Sarrazin 9, Josef Pfeilschifter 1 and Georgios Grammatikos 1,7,10,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2024, 25(22), 12175; https://doi.org/10.3390/ijms252212175
Submission received: 20 October 2024 / Revised: 9 November 2024 / Accepted: 11 November 2024 / Published: 13 November 2024
(This article belongs to the Special Issue The Relevance of Lipid Metabolism in Viral Hepatitis and Hepatocellular Carcinoma)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

please see my evaluation in the attached PDF file

Comments for author File: Comments.pdf

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

Comments and Suggestions for Authors

I found this article to be quite intriguing. While my expertise is primarily in lipid analysis via LC-MS, I believe the biological aspects are sound. To further enhance the manuscript, I suggest the following minor revisions:

The high standard deviation in MMC results warrants further discussion in the text. Why such a higher variability?

Include in the supplementary material a chromatogram of analysed samples  and/or a table with monitored transitions and retention times.

 Please adopt the current lipidomics nomenclature standards (see: 10.1194/jlr.S120001025)

Correct the labeling errors in Figure 3 and 4.

Consider using "Quantification via LC-MS" or simply "Quantification" instead of "mass spectrometric quantification".

Replace "Fig." with "Figure" in the discussion section.

Author Response

Please see the attachment

Author Response File: Author Response.docx

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