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Article

Dexmedetomidine as a Short-Use Analgesia for the Immature Nervous System

by
Anatoliy Logashkin
1,
Valentina Silaeva
1,
Arsen Mamleev
1,
Viktoria Shumkova
1,
Violetta Sitdikova
1,
Yaroslavna Popova
1,
Dmitrii Suchkov
2 and
Marat Minlebaev
1,2,*
1
Laboratory of New Engineering Solutions for Modern Laboratory Research, Kazan Federal University, Kazan 420008, Russia
2
Institut de Neurobiologie de la Méditerranée (INMED U1249), Aix-Marseille University, 13273 Marseille, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(12), 6385; https://doi.org/10.3390/ijms25126385
Submission received: 10 April 2024 / Revised: 2 June 2024 / Accepted: 5 June 2024 / Published: 9 June 2024
(This article belongs to the Special Issue Molecular Links between Sensory Nerves, Inflammation, and Pain 3.0)
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Abstract

Pain management in neonates continues to be a challenge. Diverse therapies are available that cause loss of pain sensitivity. However, because of side effects, the search for better options remains open. Dexmedetomidine is a promising drug; it has shown high efficacy with a good safety profile in sedation and analgesia in the immature nervous system. Though dexmedetomidine is already in use for pain control in neonates (including premature neonates) and infants as an adjunct to other anesthetics, the question remains whether it affects the neuronal activity patterning that is critical for development of the immature nervous system. In this study, using the neonatal rat as a model, the pharmacodynamic effects of dexmedetomidine on the nervous and cardiorespiratory systems were studied. Our results showed that dexmedetomidine has pronounced analgesic effects in the neonatal rat pups, and also weakly modified both the immature network patterns of cortical and hippocampal activity and the physiology of sleep cycles. Though the respiration and heart rates were slightly reduced after dexmedetomidine administration, it might be considered as the preferential independent short-term therapy for pain management in the immature and developing brain.
Keywords: dexmedetomidine; neonatal rat; electrophysiology; neuronal activity; pain; sleep; cortex; hippocampus dexmedetomidine; neonatal rat; electrophysiology; neuronal activity; pain; sleep; cortex; hippocampus

Share and Cite

MDPI and ACS Style

Logashkin, A.; Silaeva, V.; Mamleev, A.; Shumkova, V.; Sitdikova, V.; Popova, Y.; Suchkov, D.; Minlebaev, M. Dexmedetomidine as a Short-Use Analgesia for the Immature Nervous System. Int. J. Mol. Sci. 2024, 25, 6385. https://doi.org/10.3390/ijms25126385

AMA Style

Logashkin A, Silaeva V, Mamleev A, Shumkova V, Sitdikova V, Popova Y, Suchkov D, Minlebaev M. Dexmedetomidine as a Short-Use Analgesia for the Immature Nervous System. International Journal of Molecular Sciences. 2024; 25(12):6385. https://doi.org/10.3390/ijms25126385

Chicago/Turabian Style

Logashkin, Anatoliy, Valentina Silaeva, Arsen Mamleev, Viktoria Shumkova, Violetta Sitdikova, Yaroslavna Popova, Dmitrii Suchkov, and Marat Minlebaev. 2024. "Dexmedetomidine as a Short-Use Analgesia for the Immature Nervous System" International Journal of Molecular Sciences 25, no. 12: 6385. https://doi.org/10.3390/ijms25126385

APA Style

Logashkin, A., Silaeva, V., Mamleev, A., Shumkova, V., Sitdikova, V., Popova, Y., Suchkov, D., & Minlebaev, M. (2024). Dexmedetomidine as a Short-Use Analgesia for the Immature Nervous System. International Journal of Molecular Sciences, 25(12), 6385. https://doi.org/10.3390/ijms25126385

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