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Article

Gain-Type Aneuploidies Influence the Burden of Selective Long Non-Coding Transcripts in Colorectal Cancer

by
Chiara Scuderi
,
Virginia Di Bella
,
Anna Provvidenza Privitera
,
Francesca Maria Giustolisi
,
Vincenza Barresi
* and
Daniele Filippo Condorelli
Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(10), 5538; https://doi.org/10.3390/ijms25105538
Submission received: 29 February 2024 / Revised: 10 May 2024 / Accepted: 15 May 2024 / Published: 19 May 2024
(This article belongs to the Special Issue Transcriptional Therapy and Nucleic Acid-Based Therapeutics: From Molecular Targets to Preclinical Studies: 2nd Edition)
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Abstract

Chromosomal instability is a hallmark of colorectal carcinogenesis and produces an accumulation of different forms of aneuploidies or broad copy number aberrations. Colorectal cancer is characterized by gain-type broad copy number aberrations, specifically in Chr20, Chr8q, Chr13 and Chr7, but their roles and mechanisms in cancer progression are not fully understood. It has been suggested that broad copy number gains might contribute to tumor development through the so-called caricature transcriptomic effect. We intend to investigate the impact of broad copy number gains on long non-coding RNAs’ expression in colorectal cancer, given their well-known role in oncogenesis. The influence of such chromosomal aberrations on lncRNAs’ transcriptome profile was investigated by SNP and transcriptome arrays in our series of colorectal cancer samples and cell lines. The correlation between aneuploidies and transcriptomic profiles led us to obtain a class of Over-UpT lncRNAs, which are transcripts upregulated in CRC and further overexpressed in colon tumors bearing specific chromosomal aberrations. The identified lncRNAs can contribute to a wide interaction network to establish the cancer driving effect of gain-type aneuploidies.
Keywords: chromosome aberrations; cancer aneuploidy; transcriptome; cancer genomics; colorectal cancer; chromosomal instability; omics technologies; lncRNAs; NORAD; SNHG6 chromosome aberrations; cancer aneuploidy; transcriptome; cancer genomics; colorectal cancer; chromosomal instability; omics technologies; lncRNAs; NORAD; SNHG6

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MDPI and ACS Style

Scuderi, C.; Di Bella, V.; Privitera, A.P.; Giustolisi, F.M.; Barresi, V.; Condorelli, D.F. Gain-Type Aneuploidies Influence the Burden of Selective Long Non-Coding Transcripts in Colorectal Cancer. Int. J. Mol. Sci. 2024, 25, 5538. https://doi.org/10.3390/ijms25105538

AMA Style

Scuderi C, Di Bella V, Privitera AP, Giustolisi FM, Barresi V, Condorelli DF. Gain-Type Aneuploidies Influence the Burden of Selective Long Non-Coding Transcripts in Colorectal Cancer. International Journal of Molecular Sciences. 2024; 25(10):5538. https://doi.org/10.3390/ijms25105538

Chicago/Turabian Style

Scuderi, Chiara, Virginia Di Bella, Anna Provvidenza Privitera, Francesca Maria Giustolisi, Vincenza Barresi, and Daniele Filippo Condorelli. 2024. "Gain-Type Aneuploidies Influence the Burden of Selective Long Non-Coding Transcripts in Colorectal Cancer" International Journal of Molecular Sciences 25, no. 10: 5538. https://doi.org/10.3390/ijms25105538

APA Style

Scuderi, C., Di Bella, V., Privitera, A. P., Giustolisi, F. M., Barresi, V., & Condorelli, D. F. (2024). Gain-Type Aneuploidies Influence the Burden of Selective Long Non-Coding Transcripts in Colorectal Cancer. International Journal of Molecular Sciences, 25(10), 5538. https://doi.org/10.3390/ijms25105538

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