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Article

Probiotic Bacillus licheniformis ZW3 Alleviates DSS-Induced Colitis and Enhances Gut Homeostasis

by
Dan Jia
1,2,
Yingying Li
1,
Yingjie Wang
1,
Yanan Guo
1,
Junlong Liu
1,
Shuaiyang Zhao
1,
Jinming Wang
1,
Guiquan Guan
1,
Jianxun Luo
1,
Hong Yin
1,
Lijie Tang
2,* and
Youquan Li
1,3,*
1
State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China
2
College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
3
College of Coastal Agricultural Sciences, Department of Veterinary Medicine, Guangdong Ocean University, Zhanjiang 524088, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(1), 561; https://doi.org/10.3390/ijms25010561
Submission received: 25 November 2023 / Revised: 21 December 2023 / Accepted: 28 December 2023 / Published: 1 January 2024
(This article belongs to the Special Issue Probiotics, Prebiotics, Synbiotics and Postbiotics in Intestinal Health and Disease)
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Abstract

Despite Bacillus species having been extensively utilized in the food industry and biocontrol as part of probiotic preparations, limited knowledge exists regarding their impact on intestinal disorders. In this study, we investigated the effect of Bacillus licheniformis ZW3 (ZW3), a potential probiotic isolated from camel feces, on dextran sulfate sodium (DSS)-induced colitis. The results showed ZW3 partially mitigated body weight loss, disease activity index (DAI), colon shortening, and suppressed immune response in colitis mice, as evidenced by the reduction in the levels of the inflammatory markers IL-1β, TNF-α, and IL-6 (p < 0.05). ZW3 was found to ameliorate DSS-induced dysfunction of the colonic barrier by enhancing mucin 2 (MUC2), zonula occluden-1 (ZO-1), and occludin. Furthermore, enriched beneficial bacteria Lachnospiraceae_NK4A136_group and decreased harmful bacteria Escherichia-Shigella revealed that ZW3 improved the imbalanced gut microbiota. Abnormally elevated uric acid levels in colitis were further normalized upon ZW3 supplementation. Overall, this study emphasized the protective effects of ZW3 in colitis mice as well as some potential applications in the management of inflammation-related diseases.
Keywords: Bacillus licheniformis; colitis; intestinal mucosal barrier; gut microbiota; purine metabolite; uric acid Bacillus licheniformis; colitis; intestinal mucosal barrier; gut microbiota; purine metabolite; uric acid

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MDPI and ACS Style

Jia, D.; Li, Y.; Wang, Y.; Guo, Y.; Liu, J.; Zhao, S.; Wang, J.; Guan, G.; Luo, J.; Yin, H.; et al. Probiotic Bacillus licheniformis ZW3 Alleviates DSS-Induced Colitis and Enhances Gut Homeostasis. Int. J. Mol. Sci. 2024, 25, 561. https://doi.org/10.3390/ijms25010561

AMA Style

Jia D, Li Y, Wang Y, Guo Y, Liu J, Zhao S, Wang J, Guan G, Luo J, Yin H, et al. Probiotic Bacillus licheniformis ZW3 Alleviates DSS-Induced Colitis and Enhances Gut Homeostasis. International Journal of Molecular Sciences. 2024; 25(1):561. https://doi.org/10.3390/ijms25010561

Chicago/Turabian Style

Jia, Dan, Yingying Li, Yingjie Wang, Yanan Guo, Junlong Liu, Shuaiyang Zhao, Jinming Wang, Guiquan Guan, Jianxun Luo, Hong Yin, and et al. 2024. "Probiotic Bacillus licheniformis ZW3 Alleviates DSS-Induced Colitis and Enhances Gut Homeostasis" International Journal of Molecular Sciences 25, no. 1: 561. https://doi.org/10.3390/ijms25010561

APA Style

Jia, D., Li, Y., Wang, Y., Guo, Y., Liu, J., Zhao, S., Wang, J., Guan, G., Luo, J., Yin, H., Tang, L., & Li, Y. (2024). Probiotic Bacillus licheniformis ZW3 Alleviates DSS-Induced Colitis and Enhances Gut Homeostasis. International Journal of Molecular Sciences, 25(1), 561. https://doi.org/10.3390/ijms25010561

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