HSA-ZW800-PEG for Enhanced Optophysical Stability and Tumor Targeting
Abstract
:1. Introduction
2. Results
2.1. Synthesis and Optical Characterization of HSA-ZW800-PEG
2.2. In Vitro Optophysical Stability
2.3. In Vivo Biodistribution and Pharmacokinetics
2.4. Tumor Targetability and Cytotoxicity Assay
3. Discussion
4. Materials and Methods
4.1. Synthesis and Purification of HSA-ZW800-PEG
4.2. Determination of Molar Absorptivity and Labeling Ratio
4.3. Photostability Assay Using NIR Light
4.4. In Vivo Biodistribution and Pharmacokinetics
4.5. Cellular Uptake and Viability Tests for ZW800-PEG and HSA-ZW800-PEG
4.6. In Vitro Inhibition Study
4.7. Tumor-Bearing Mouse Models
4.8. Quantitative and Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Jang, P.; Ser, J.; Cardenas, K.; Kim, H.J.; Hickey, M.; Jang, J.; Gladstone, J.; Bailey, A.; Dinh, J.; Nguyen, V.; et al. HSA-ZW800-PEG for Enhanced Optophysical Stability and Tumor Targeting. Int. J. Mol. Sci. 2024, 25, 559. https://doi.org/10.3390/ijms25010559
Jang P, Ser J, Cardenas K, Kim HJ, Hickey M, Jang J, Gladstone J, Bailey A, Dinh J, Nguyen V, et al. HSA-ZW800-PEG for Enhanced Optophysical Stability and Tumor Targeting. International Journal of Molecular Sciences. 2024; 25(1):559. https://doi.org/10.3390/ijms25010559
Chicago/Turabian StyleJang, Paul, Jinhui Ser, Kevin Cardenas, Hajin Joanne Kim, Morgan Hickey, Jiseon Jang, Jason Gladstone, Aisha Bailey, Jason Dinh, Vy Nguyen, and et al. 2024. "HSA-ZW800-PEG for Enhanced Optophysical Stability and Tumor Targeting" International Journal of Molecular Sciences 25, no. 1: 559. https://doi.org/10.3390/ijms25010559