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Article

Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis

by
Monika Abramiuk
1,*,
Karolina Frankowska
2,
Krzysztof Kułak
3,
Rafał Tarkowski
3,
Paulina Mertowska
4,
Sebastian Mertowski
4 and
Ewelina Grywalska
4
1
Independent Laboratory of Minimally Invasive Gynecology and Gynecological Endocrinology, Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Staszica 16 St., 20-081 Lublin, Poland
2
1st Chair and Department of Oncological Gynaecology and Gynaecology, Student Scientific Association, Medical University of Lublin, Staszica 16 St., 20-081 Lublin, Poland
3
1st Chair and Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Staszica 16 St., 20-081 Lublin, Poland
4
Department of Experimental Immunology, Medical University of Lublin, Chodźki 4a St., 20-093 Lublin, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(9), 7787; https://doi.org/10.3390/ijms24097787
Submission received: 16 March 2023 / Revised: 20 April 2023 / Accepted: 22 April 2023 / Published: 24 April 2023
(This article belongs to the Special Issue Molecular Research in Gynecological Diseases)
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Abstract

The etiology of endometriosis (EMS) has not been clearly elucidated yet, and that is probably the reason why its diagnostic process is frequently long-lasting and inefficient. Nowadays, the non-invasive diagnostic methods of EMS are still being sought. Our study aimed to assess the serum and peritoneal fluid levels of urocortin 1 (Ucn1) in patients with EMS and healthy women. Moreover, considering the immune background of the disease, the association between Ucn1 and several immune parameters was studied in both groups. We found that the serum Ucn1 level was significantly upregulated in women with EMS compared to healthy patients. Moreover, higher serum Ucn1 levels tended to correspond with more advanced stages of the disease (p = 0.031). Receiver operating characteristic (ROC) analysis revealed that based on serum Ucn1 levels, it is possible to distinguish deep infiltrating endometriosis (DIE) from among other EMS types. Together, these results indicate Ucn1 as a possible promising biomarker of EMS: however, not in isolation, but rather to enhance the effectiveness of other diagnostic methods.
Keywords: endometriosis; urocortin 1; deep infiltrating endometriosis; immune system; interleukins; ovarian endometrioma; peritoneal endometriosis endometriosis; urocortin 1; deep infiltrating endometriosis; immune system; interleukins; ovarian endometrioma; peritoneal endometriosis

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MDPI and ACS Style

Abramiuk, M.; Frankowska, K.; Kułak, K.; Tarkowski, R.; Mertowska, P.; Mertowski, S.; Grywalska, E. Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis. Int. J. Mol. Sci. 2023, 24, 7787. https://doi.org/10.3390/ijms24097787

AMA Style

Abramiuk M, Frankowska K, Kułak K, Tarkowski R, Mertowska P, Mertowski S, Grywalska E. Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis. International Journal of Molecular Sciences. 2023; 24(9):7787. https://doi.org/10.3390/ijms24097787

Chicago/Turabian Style

Abramiuk, Monika, Karolina Frankowska, Krzysztof Kułak, Rafał Tarkowski, Paulina Mertowska, Sebastian Mertowski, and Ewelina Grywalska. 2023. "Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis" International Journal of Molecular Sciences 24, no. 9: 7787. https://doi.org/10.3390/ijms24097787

APA Style

Abramiuk, M., Frankowska, K., Kułak, K., Tarkowski, R., Mertowska, P., Mertowski, S., & Grywalska, E. (2023). Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis. International Journal of Molecular Sciences, 24(9), 7787. https://doi.org/10.3390/ijms24097787

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