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Article

Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis

by
Tsuyoshi Suda
1,
Hajime Takatori
1,*,
Takehiro Hayashi
1,
Kiichiro Kaji
1,
Kouki Nio
1,
Takeshi Terashima
1,
Tetsuro Shimakami
1,
Kuniaki Arai
1,
Tatsuya Yamashita
1,
Eishiro Mizukoshi
1,
Masao Honda
1,
Kenichiro Okumura
2,
Kazuto Kozaka
2 and
Taro Yamashita
1
1
Department of Gastroenterology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8641, Japan
2
Department of Radiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8641, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(9), 7732; https://doi.org/10.3390/ijms24097732
Submission received: 28 January 2023 / Revised: 12 April 2023 / Accepted: 20 April 2023 / Published: 23 April 2023
(This article belongs to the Special Issue New Advances in Thrombosis)
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Abstract

Liver function influences the plasma antithrombin (AT)-III levels. AT-III is beneficial for patients with portal vein thrombosis (PVT) and low plasma AT-III levels. However, whether these levels affect prognosis in patients with cirrhosis-associated PVT remains unknown. This retrospective study involved 75 patients with cirrhosis and PVT treated with danaparoid sodium with or without AT-III. The plasma AT-III level was significantly lower in patients with liver failure-related death than in those with hepatocellular carcinoma (HCC)-related death (p = 0.005), although the Child–Pugh and albumin-bilirubin (ALBI) scores were not significantly different between these two groups. Receiver operating characteristic curve analysis of the plasma AT-III levels showed cutoff values of 54.0% at 5-year survival. Low plasma AT-III levels (<54.0%) were associated with significantly worse prognosis than high levels in both overall survival (p = 0.0013) and survival excluding HCC-related death (p < 0.0001). Low plasma AT-III (<54.0%) was also associated with a significantly worse prognosis among patients with Child–Pugh A/B or ALBI grade 1/2 (p < 0.0001). Multivariate analyses indicated that low plasma AT-III levels (<54.0%) were an independent prognostic factor for poor survival outcome. Low plasma AT-III levels may be associated with mortality, particularly liver failure-related death, independent of liver function.
Keywords: portal vein thrombosis; cirrhosis; antithrombin III; prognosis; liver failure portal vein thrombosis; cirrhosis; antithrombin III; prognosis; liver failure

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MDPI and ACS Style

Suda, T.; Takatori, H.; Hayashi, T.; Kaji, K.; Nio, K.; Terashima, T.; Shimakami, T.; Arai, K.; Yamashita, T.; Mizukoshi, E.; et al. Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis. Int. J. Mol. Sci. 2023, 24, 7732. https://doi.org/10.3390/ijms24097732

AMA Style

Suda T, Takatori H, Hayashi T, Kaji K, Nio K, Terashima T, Shimakami T, Arai K, Yamashita T, Mizukoshi E, et al. Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis. International Journal of Molecular Sciences. 2023; 24(9):7732. https://doi.org/10.3390/ijms24097732

Chicago/Turabian Style

Suda, Tsuyoshi, Hajime Takatori, Takehiro Hayashi, Kiichiro Kaji, Kouki Nio, Takeshi Terashima, Tetsuro Shimakami, Kuniaki Arai, Tatsuya Yamashita, Eishiro Mizukoshi, and et al. 2023. "Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis" International Journal of Molecular Sciences 24, no. 9: 7732. https://doi.org/10.3390/ijms24097732

APA Style

Suda, T., Takatori, H., Hayashi, T., Kaji, K., Nio, K., Terashima, T., Shimakami, T., Arai, K., Yamashita, T., Mizukoshi, E., Honda, M., Okumura, K., Kozaka, K., & Yamashita, T. (2023). Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis. International Journal of Molecular Sciences, 24(9), 7732. https://doi.org/10.3390/ijms24097732

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