Influence of Fasting until Noon (Extended Postabsorptive State) on Clock Gene mRNA Expression and Regulation of Body Weight and Glucose Metabolism

Jakubowicz, Daniela; Rosenblum, Rachel Chava; Wainstein, Julio; Twito, Orit

doi:10.3390/ijms24087154

Open AccessReview

Influence of Fasting until Noon (Extended Postabsorptive State) on Clock Gene mRNA Expression and Regulation of Body Weight and Glucose Metabolism

by

Daniela Jakubowicz

^*,

Rachel Chava Rosenblum

,

Julio Wainstein

and

Orit Twito

Endocrinology and Diabetes Unit, Wolfson Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Holon 58100, Israel

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2023, 24(8), 7154; https://doi.org/10.3390/ijms24087154

Submission received: 3 March 2023 / Revised: 7 April 2023 / Accepted: 10 April 2023 / Published: 12 April 2023

(This article belongs to the Special Issue Nutrition and Metabolism in Health and Disease: From Gene to Organism)

Download

Browse Figures

Review Reports Versions Notes

Abstract

The trend of fasting until noon (omission or delayed breakfast) is increasingly prevalent in modern society. This eating pattern triggers discordance between endogenous circadian clock rhythms and the feeding/fasting cycle and is associated with an increased incidence of obesity and T2D. Although the underlying mechanism of this association is not well understood, growing evidence suggests that fasting until noon, also known as an “extended postabsorptive state”, has the potential to cause a deleterious effect on clock gene expression and to disrupt regulation of body weight, postprandial and overall glycemia, skeletal muscle protein synthesis, and appetite, and may also lead to lower energy expenditure. This manuscript overviews the clock gene-controlled glucose metabolism during the active and resting phases and the consequences of postponing until noon the transition from postabsorptive to fed state on glucose metabolism, weight control, and energy expenditure. Finally, we will discuss the metabolic advantages of shifting more energy, carbohydrates (CH), and proteins to the early hours of the day.

Keywords: fasting until noon; circadian clock genes; fasting until noon; weight loss; overall glycemia; diet induced thermogenesis

Share and Cite

MDPI and ACS Style

Jakubowicz, D.; Rosenblum, R.C.; Wainstein, J.; Twito, O. Influence of Fasting until Noon (Extended Postabsorptive State) on Clock Gene mRNA Expression and Regulation of Body Weight and Glucose Metabolism. Int. J. Mol. Sci. 2023, 24, 7154. https://doi.org/10.3390/ijms24087154

AMA Style

Jakubowicz D, Rosenblum RC, Wainstein J, Twito O. Influence of Fasting until Noon (Extended Postabsorptive State) on Clock Gene mRNA Expression and Regulation of Body Weight and Glucose Metabolism. International Journal of Molecular Sciences. 2023; 24(8):7154. https://doi.org/10.3390/ijms24087154

Chicago/Turabian Style

Jakubowicz, Daniela, Rachel Chava Rosenblum, Julio Wainstein, and Orit Twito. 2023. "Influence of Fasting until Noon (Extended Postabsorptive State) on Clock Gene mRNA Expression and Regulation of Body Weight and Glucose Metabolism" International Journal of Molecular Sciences 24, no. 8: 7154. https://doi.org/10.3390/ijms24087154

APA Style

Jakubowicz, D., Rosenblum, R. C., Wainstein, J., & Twito, O. (2023). Influence of Fasting until Noon (Extended Postabsorptive State) on Clock Gene mRNA Expression and Regulation of Body Weight and Glucose Metabolism. International Journal of Molecular Sciences, 24(8), 7154. https://doi.org/10.3390/ijms24087154

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Influence of Fasting until Noon (Extended Postabsorptive State) on Clock Gene mRNA Expression and Regulation of Body Weight and Glucose Metabolism

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI