Small Extracellular Vesicles Derived from Induced Pluripotent Stem Cells in the Treatment of Myocardial Injury
Abstract
:1. Introduction
2. Isolation of sEVs from Induced Pluripotent Stem Cells
3. Drug Delivery of iPSC-sEVs in the Repair of Myocardial Injury
4. Mechanism of iPSC-sEVs in the Repair of Myocardial Injury
4.1. MI
4.2. MIRI
4.3. Coronary Heart Disease
4.4. HF
5. Challenges in the Treatment of CVD with IPSC-sEVs
6. Prospects and Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Cell Sources | Characterization | Models | Therapeutic Effects | Cargos | Reference |
---|---|---|---|---|---|
miPSCs | TEM | MI | Mitigate cardiac remodeling and improve cardiac functions post myocardial infarction | [81] | |
miPSCs | WB (CD63, Tsg101) | MIRI | Prevent cardiomyocyte apoptosis in ischemic myocardium | miR21, HIF-1α-regulated miR210 | [82] |
miPSCs | EM, FCM, RT-PCR | MIRI | Improve LV function and enhance angiogenesis | global miRNA and proteomic profiling performed | [21] |
hiPSCs | FCM, BCA | MI | Reduce fibrosis in infarcted mice hearts | CD82 | [83] |
hiPSCs | TEM, NTA | MI | Facilitate cardiac repair through circulating miRNAs | circulating miRNAs | [84] |
hiPSCs | NTA, WB (CD63) | HF | Involved in the remodeling process and observed in primary cardiomyocytes | miRNA mRNA | [85] |
hiPSCs | TEM, WB (CD63, CD9) | Endothelial cell in vitro | Improve cardiac function and repair | miRNA | [86] |
hiPSCs | TEM, NTA | H9c2 in vitro | Protect against oxidative-stress-induced apoptosis | miRNA | [87] |
hiCMs | WB (CD63, CD81) | Dys-iCMs In vitro | Decrease reactive oxygen species and delay mitochondrial permeability | [88] | |
hiCMs | TEM, WB (CD63, CD81) | MI | Facilitate cardiac repair and avoid immune rejection | miRNA, LncRNA | [89] |
hiCMs | WB (CD81, CD63, flotillin-1, TSTG101) | MI | Improve recovery from myocardial infarction in swine | [12] | |
hiMSCs | EM, NanoFCM | MI | Promote cell viability through activating the Akt/Nrf2/HO-1 axis and improve cardiac function | [90] | |
hiMSCs | TEM, immunoblot | Rat skin wound model | Promote collagen synthesis and angiogenesis | [91] | |
hiMSCs | EM, NTA | HF | Improve cardiac function and increased EF relative to baseline values | miRNA | [92] |
hiMSCs | TEM, NTA, RT-PCR | Ischemic Adult Human Cardiomyocytes | Alter cardiac tissue-level remodeling | miR21-5p | [93] |
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Meng, W.-T.; Guo, H.-D. Small Extracellular Vesicles Derived from Induced Pluripotent Stem Cells in the Treatment of Myocardial Injury. Int. J. Mol. Sci. 2023, 24, 4577. https://doi.org/10.3390/ijms24054577
Meng W-T, Guo H-D. Small Extracellular Vesicles Derived from Induced Pluripotent Stem Cells in the Treatment of Myocardial Injury. International Journal of Molecular Sciences. 2023; 24(5):4577. https://doi.org/10.3390/ijms24054577
Chicago/Turabian StyleMeng, Wan-Ting, and Hai-Dong Guo. 2023. "Small Extracellular Vesicles Derived from Induced Pluripotent Stem Cells in the Treatment of Myocardial Injury" International Journal of Molecular Sciences 24, no. 5: 4577. https://doi.org/10.3390/ijms24054577