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Volume 24
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10.3390/ijms24043560
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Article

NMDA Receptors in Health and Diseases: New Roles and Signaling Pathways—Anti-N-Methyl-D-Aspartate Receptor (NMDAR) Autoantibodies as Potential Biomarkers of Fatigue in Patients with Rheumatic Diseases

by
Tatjana Marinoska
1,*,
Tamara Möckel
2,
Konstantinos Triantafyllias
1,2,
Sebastian Boegel
2,
Matthias Dreher
2,3,
Felix Luessi
3,4 and
Andreas Schwarting
1,2,3,*
1
Center for Rheumatic Disease Rhineland-Palatinate, 55543 Bad Kreuznach, Germany
2
Division of Rheumatology and Clinical Immunology, University Medical Center of the Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
3
University Center for Autoimmune Disease, University Medical Center of the Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
4
Division of Neurology, University Medical Center of the Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(4), 3560; https://doi.org/10.3390/ijms24043560
Submission received: 14 December 2022 / Revised: 30 January 2023 / Accepted: 31 January 2023 / Published: 10 February 2023
(This article belongs to the Special Issue NMDA Receptors in Health and Diseases: New Roles and Signaling Pathways)
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Abstract

Fatigue is a widespread and complex symptom with motor and cognitive components; it is diagnosed predominantly by questionnaire. We recently published a correlation between anti-N-methyl-D-aspartate receptor (NMDAR) antibodies and fatigue in patients with SLE (systemic lupus erythematosus). In the present study, we examined whether this association also applies to patients with other rheumatic diseases. Serum samples of 88 patients with different rheumatic diseases were analyzed for the presence of anti-NR2 antibodies and Neurofilament light chain (NfL) protein. The severity of fatigue was determined according to the FSMC questionnaire (Fatigue Scale for Motor and Cognitive Functions) and correlated with the circulating antibody titer and NfL level accordingly. Positive titers of anti-NR2 antibodies were detected in patients with both autoimmune and non-autoimmune rheumatic diseases. These patients suffer predominantly from severe fatigue. The circulating NfL level did not correlate with the anti-NR2 titer and the fatigue severity in all patient groups. The association of severe fatigue with circulating anti-NR2 antibodies in patients with rheumatic diseases, independently from the main disease, suggests an individual role of these autoantibodies in fatigue pathophysiology. Thus, the detection of these autoantibodies might be a helpful diagnostic tool in rheumatic patients with fatigue.
Keywords: anti-NMDAR2 antibodies; fatigue; rheumatic diseases; neurofilament light chain anti-NMDAR2 antibodies; fatigue; rheumatic diseases; neurofilament light chain

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MDPI and ACS Style

Marinoska, T.; Möckel, T.; Triantafyllias, K.; Boegel, S.; Dreher, M.; Luessi, F.; Schwarting, A. NMDA Receptors in Health and Diseases: New Roles and Signaling Pathways—Anti-N-Methyl-D-Aspartate Receptor (NMDAR) Autoantibodies as Potential Biomarkers of Fatigue in Patients with Rheumatic Diseases. Int. J. Mol. Sci. 2023, 24, 3560. https://doi.org/10.3390/ijms24043560

AMA Style

Marinoska T, Möckel T, Triantafyllias K, Boegel S, Dreher M, Luessi F, Schwarting A. NMDA Receptors in Health and Diseases: New Roles and Signaling Pathways—Anti-N-Methyl-D-Aspartate Receptor (NMDAR) Autoantibodies as Potential Biomarkers of Fatigue in Patients with Rheumatic Diseases. International Journal of Molecular Sciences. 2023; 24(4):3560. https://doi.org/10.3390/ijms24043560

Chicago/Turabian Style

Marinoska, Tatjana, Tamara Möckel, Konstantinos Triantafyllias, Sebastian Boegel, Matthias Dreher, Felix Luessi, and Andreas Schwarting. 2023. "NMDA Receptors in Health and Diseases: New Roles and Signaling Pathways—Anti-N-Methyl-D-Aspartate Receptor (NMDAR) Autoantibodies as Potential Biomarkers of Fatigue in Patients with Rheumatic Diseases" International Journal of Molecular Sciences 24, no. 4: 3560. https://doi.org/10.3390/ijms24043560

APA Style

Marinoska, T., Möckel, T., Triantafyllias, K., Boegel, S., Dreher, M., Luessi, F., & Schwarting, A. (2023). NMDA Receptors in Health and Diseases: New Roles and Signaling Pathways—Anti-N-Methyl-D-Aspartate Receptor (NMDAR) Autoantibodies as Potential Biomarkers of Fatigue in Patients with Rheumatic Diseases. International Journal of Molecular Sciences, 24(4), 3560. https://doi.org/10.3390/ijms24043560

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