Defining the Role of the Gut Microbiome in the Pathogenesis and Treatment of Lymphoid Malignancies
Abstract
:1. Introduction
2. Microbiome Environments and Lymphomagenesis
3. Immune-Mediated Mechanisms of Lymphoma Development and Therapy
3.1. Dendritic Cell Activation
3.2. T Cell Activation
3.3. Effects of Gut-Associated Metabolites
4. Clinical Implications of the Gut Microbiome in Lymphoma Diagnosis and Therapy
4.1. Lymphoma/Myeloma Diagnosis
4.2. Chemotherapy/Immunotherapy
4.3. Autologous Stem Cell Transplantation
4.4. Allogeneic Stem Cell Transplantation
4.5. CAR T Cell Therapy
4.6. Gut-Microbiome-Directed Interventions
5. Future Directions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Brief Study Title | Disease/Population | Intervention | Status |
---|---|---|---|
Choosing the best antibiotic to protect the gut microbiota during stem-cell transplant | Allo-HSCT for any hematologic malignancies | Piperacillin-tazobactam versus cefepime for the treatment of neutropenic fever | Recruiting (NCT03078010) |
Prebiotics during ASCT for lymphoma/myeloma (PRIMAL) | Allo-SCT for lymphoma /myeloma | Resistant potato starch | Recruiting (NCT05135351) |
Plant-based diet for MGUS and smoldering myeloma | Monoclonal gammopathy of undetermined significance or smoldering myeloma | Plant-based diet | Recruiting (NCT04920084) |
Effects of prebiotics on the gut microbiome in patients undergoing HSCT (HCTDiet) | Allo-HSCT for lymphoma | Prebiotic foods | Recruiting (NCT04629430) |
Dietary manipulation of the microbiome-metabolomic axis for GVHD mitigation | Allo-HSCT for lymphoma | Resistant potato starch | Recruiting (NCT02763033) |
Intermittent fasting and CLL/SLL | Chronic lymphocytic leukemia or small lymphocytic leukemia | Intermittent fasting | Active, Not recruiting (NCT04629430) |
Fecal microbial transplant after allogeneic stem cell Transplantation | Allo-HSCT for any hematologic malignancies | FMT | Not yet recruiting (NCT04935684) |
A novel vaccine as monotherapy or combination therapy in indolent NHL | Follicular and marginal zone lymphoma | Tumor-antigen or microbiome peptide vaccine | Recruiting (NCT04669171) |
Safety and efficacy of curcumin in children with ALL (CurCumPedALL) | Acute lymphoblastic leukemia | Curcumin | Recruiting (NCT05045443) |
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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Upadhyay Banskota, S.; Skupa, S.A.; El-Gamal, D.; D’Angelo, C.R. Defining the Role of the Gut Microbiome in the Pathogenesis and Treatment of Lymphoid Malignancies. Int. J. Mol. Sci. 2023, 24, 2309. https://doi.org/10.3390/ijms24032309
Upadhyay Banskota S, Skupa SA, El-Gamal D, D’Angelo CR. Defining the Role of the Gut Microbiome in the Pathogenesis and Treatment of Lymphoid Malignancies. International Journal of Molecular Sciences. 2023; 24(3):2309. https://doi.org/10.3390/ijms24032309
Chicago/Turabian StyleUpadhyay Banskota, Shristi, Sydney A. Skupa, Dalia El-Gamal, and Christopher R. D’Angelo. 2023. "Defining the Role of the Gut Microbiome in the Pathogenesis and Treatment of Lymphoid Malignancies" International Journal of Molecular Sciences 24, no. 3: 2309. https://doi.org/10.3390/ijms24032309
APA StyleUpadhyay Banskota, S., Skupa, S. A., El-Gamal, D., & D’Angelo, C. R. (2023). Defining the Role of the Gut Microbiome in the Pathogenesis and Treatment of Lymphoid Malignancies. International Journal of Molecular Sciences, 24(3), 2309. https://doi.org/10.3390/ijms24032309