Unsymmetrical Pd(II) Pincer Complexes with Benzothiazole and Thiocarbamate Flanking Units: Expedient Solvent-Free Synthesis and Anticancer Potential
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
3.1. General Remarks
3.2. Syntheses
3.2.1. O-[3-(Benzo[d]thiazol-2-yl)phenyl] Dimethylthiocarbamate, 1a
3.2.2. O-[3-(Benzo[d]thiazol-2-yl)phenyl] Diethylthiocarbamate, 1b
3.2.3. Solution-Based Synthesis and Characterization of [κ3-S,C,N-(L)Pd(II)Cl] Complex 2a
3.2.4. Solution-Based Synthesis and Characterization of [κ3-S,C,N-(L)Pd(II)Cl] Complex 2b
3.2.5. Solid-Phase Synthesis of [κ3-S,C,N-(L)Pd(II)Cl] Complexes 2a,b
3.3. X-ray Crystallography
3.4. Powder X-ray Diffraction Analysis
3.5. Bioactivity Studies
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Cell Lines | IC50 ± SD 1, μM | |||
---|---|---|---|---|
2a | 2b | VI (X = O) | Cisplatin | |
Solid cancer cell lines | ||||
HCT116 | 1.3 ± 0.2 | 12.7 ± 1.5 | 10.3 ± 0.8 | 18.0 ± 2.0 |
MCF7 | 3.3 ± 0.4 | 13.5 ± 2.1 | 17.0 ± 0.5 | 25.0 ± 4.0 |
PC3 | 1.1 ± 0.3 | 8.5 ± 2.5 | 6.6 ± 0.6 | 16.0 ± 3.0 |
Hematopoietic cancer cell lines | ||||
K562 | 0.9 ± 0.2 | 2.9 ± 0.4 | 1.9 ± 0.3 | 15.5 ± 0.5 |
K562/iS9 | 0.9 ± 0.1 | 2.6 ± 0.8 | 2.5 ± 0.4 | 16.0 ± 2.0 |
AMO1 | 0.3 ± 0.1 | 4.4 ± 0.8 | 3.4 ± 0.5 | 3.2 ± 0.6 |
H9 | 1.3 ± 0.1 | 2.1 ± 0.9 | 1.7 ± 0.3 | 3.0 ± 1.0 |
Non-cancerous cell lines | ||||
HEK293 | 2.5 ± 0.2 | 9.5 ± 0.7 | 13.0 ± 0.5 | 12.5 ± 1.5 |
HBL100 | 3.2 ± 0.5 | 10.2 ± 3.3 | 9.4 ± 0.9 | 14.6 ± 3.6 |
HBL100/dox | 4.4 ± 0.8 | 16.3 ± 3.8 | 28.6 ± 3.8 | 23.6 ± 3.6 |
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Kozlov, V.A.; Aleksanyan, D.V.; Churusova, S.G.; Spiridonov, A.A.; Rybalkina, E.Y.; Gutsul, E.I.; Aksenova, S.A.; Korlyukov, A.A.; Peregudov, A.S.; Klemenkova, Z.S. Unsymmetrical Pd(II) Pincer Complexes with Benzothiazole and Thiocarbamate Flanking Units: Expedient Solvent-Free Synthesis and Anticancer Potential. Int. J. Mol. Sci. 2023, 24, 17331. https://doi.org/10.3390/ijms242417331
Kozlov VA, Aleksanyan DV, Churusova SG, Spiridonov AA, Rybalkina EY, Gutsul EI, Aksenova SA, Korlyukov AA, Peregudov AS, Klemenkova ZS. Unsymmetrical Pd(II) Pincer Complexes with Benzothiazole and Thiocarbamate Flanking Units: Expedient Solvent-Free Synthesis and Anticancer Potential. International Journal of Molecular Sciences. 2023; 24(24):17331. https://doi.org/10.3390/ijms242417331
Chicago/Turabian StyleKozlov, Vladimir A., Diana V. Aleksanyan, Svetlana G. Churusova, Aleksandr A. Spiridonov, Ekaterina Yu. Rybalkina, Evgenii I. Gutsul, Svetlana A. Aksenova, Alexander A. Korlyukov, Alexander S. Peregudov, and Zinaida S. Klemenkova. 2023. "Unsymmetrical Pd(II) Pincer Complexes with Benzothiazole and Thiocarbamate Flanking Units: Expedient Solvent-Free Synthesis and Anticancer Potential" International Journal of Molecular Sciences 24, no. 24: 17331. https://doi.org/10.3390/ijms242417331