Advances in Detection Techniques for the H5N1 Avian Influenza Virus
Abstract
:1. Introduction
2. Virus Isolation and Identification
3. Serological Detection Technology
3.1. HA and HI Test
3.2. Enzyme-Linked Immunosorbent Assays (ELISA)
4. Immunological Detection Technology
4.1. Collagen Gold Immunochromatography Technology
4.2. Fluorescence Immunodetection Technique
5. Molecular Biological Detection Technology
5.1. Reverse-Transcription Polymerase Chain Reaction (RT-PCR)
5.2. Recombinase Polymerase Amplification (RPA)
5.3. Loop-Mediated Isothermal Amplification (LAMP)
5.4. Nuclear Acid Sequence-Based Amplification (NASBA)
6. Gene Testing Technology
6.1. Gene Chip
6.2. Next-Generation Sequencing (NGS)
7. Biosensor
7.1. Surface Plasmon Resonance (SPR)
7.2. Field-Effect Transistor (FET)
7.3. Electrochemical Biosensor
7.4. Gene Biosensor
7.5. Impedance Biosensor
8. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Category | Technology | Sensitivity (%) | Specificity (%) | LOD | Reference |
---|---|---|---|---|---|
Serology | ELISA | 95 | 100 | 2.5 × 102 EID50 | [36] |
Immunology | (1) Collagen Gold Immunochromatography Technology | 100 | 100 | 1 mL of allantoic fluid (HA titer 1:27) continuously diluted 1:100–1:1000 | [132] |
(2) Fluorescence Immunodetection Technique | 78.57 | 97.37 | 80 HAU/mL | [49] | |
Molecular biology | (1) RT-PCR | 80 | 100 | 100 copies/reaction | [56] |
(2) RPA | 97.26 | 100 | 102cRNA copies/μL | [69] | |
(3) LAMP | 100 | 87.5 | 1 PFU/tube | [75] | |
(4) NASBA | - | - | 10 copies/reaction | [89] | |
Genetics | Gene chip | 97 | 100 | - | [93] |
Biosensor | (1) SPR | - | - | 0.128–12.8 HAU | [105] |
(2) FET | - | - | 1fM | [109] | |
(3) Electrochemical biosensor | - | - | 5.2 × 10−14 M | [120] | |
(4) Gene biosensor | - | - | 100pM | [123] | |
(5) Impedance biosensor | - | - | 0.25 HAU | [133] |
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Fu, X.; Wang, Q.; Ma, B.; Zhang, B.; Sun, K.; Yu, X.; Ye, Z.; Zhang, M. Advances in Detection Techniques for the H5N1 Avian Influenza Virus. Int. J. Mol. Sci. 2023, 24, 17157. https://doi.org/10.3390/ijms242417157
Fu X, Wang Q, Ma B, Zhang B, Sun K, Yu X, Ye Z, Zhang M. Advances in Detection Techniques for the H5N1 Avian Influenza Virus. International Journal of Molecular Sciences. 2023; 24(24):17157. https://doi.org/10.3390/ijms242417157
Chicago/Turabian StyleFu, Xianshu, Qian Wang, Biao Ma, Biao Zhang, Kai Sun, Xiaoping Yu, Zihong Ye, and Mingzhou Zhang. 2023. "Advances in Detection Techniques for the H5N1 Avian Influenza Virus" International Journal of Molecular Sciences 24, no. 24: 17157. https://doi.org/10.3390/ijms242417157