Relevance of Phytochemical Taste for Anti-Cancer Activity: A Statistical Inquiry
Abstract
:1. Introduction
2. Results
2.1. The Correlation between Anti-Inflammatory/Anti-Cancer Activity and Taste/Chemical Class
2.2. Correlation between Anti-Cancer and Anti-Inflammatory Activity
3. Discussion
3.1. Taste as an Important Determinant of Pharmacodynamic Activity
3.2. Upgrade of the Previously Reported Taste—AIA Associations
3.3. The Pharmacodynamic Activity of Phytochemicals: Taste Has Predictive Primacy over Chemical Classes
3.4. Bitter—Sweet: Are They in Opposition?
3.5. Anti-Inflammatory Activity- Anti-Cancer Activity Association Is Independent of Taste
3.6. Anti-Cancer Activity—Is Bitter Better?
3.7. Anti-Cancer Activity—Is Sweet Worse?
3.8. Limitations of the Study
4. Materials and Methods
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
ACA | anti-cancer activity |
AIA | anti-inflammatory activity |
chemClass | chemical class |
PMTDB | PlantMolecularTasteDB |
PDA | pharmacodynamic activity |
TASRs | taste receptors |
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Taste/Orosensation | PDA | (a, b, c, d) | Odds Ratio (OR) | 95% Confidence Interval for OR | p-Value |
---|---|---|---|---|---|
Astringent | ACA | (75, 17, 386, 146) | 1.67 | 0.97-2.99 | 0.073 |
Bitter (flavonoids only) | ACA | (57, 0, 5, 2) | Infinity | __ | 0.01 |
Bitter | ACA | (324, 90, 137, 73) | 1.92 | 1.32–2.77 | 7 × 10−4 |
Pungent | ACA | (64, 18, 397, 145) | 1.3 | 0.75–2.32 | 0.42 |
Salty | ACA | (2, 2, 459, 161) | 0.35 | 0.04–3.4 | 0.28 |
Sour | ACA | (29, 19, 432, 144) | 0.51 | 0.28–0.95 | 0.039 |
Sweet | ACA | (55, 45, 406, 118) | 0.36 | 0.23–0.56 | 1 × 10−5 |
Umami | ACA | (4, 5, 457, 158) | 0.28 | 0.07–1.11 | 0.057 |
Astringent | AIA | (82, 10, 429, 103) | 1.97 | 1.01–4.13 | 0.056 |
Bitter | AIA | (353, 61, 158, 52) | 1.9 | 1.25–2.88 | 0.003 |
Pungent | AIA | (70, 12, 441, 101) | 1.34 | 0.71–2.66 | 0.44 |
Salty | AIA | (3, 1, 508, 112) | 0.66 | 0.07–17.56 | 0.55 |
Sour | AIA | (37, 11, 474, 102) | 0.72 | 0.36–1.53 | 0.43 |
Sweet | AIA | (73, 27, 438, 86) | 0.53 | 0.32–0.88 | 0.016 |
Umami | AIA | (6, 3, 505, 110) | 0.44 | 0.11–2.16 | 0.21 |
Chemical Class | PDA | (a, b, c, d) | Odds Ratio (OR) | 95% Confidence Interval for OR | p-Value |
---|---|---|---|---|---|
alkaloids | ACA | (71, 37, 390, 126) | 0.62 | 0.4–0.98 | 0.04 |
flavonoids | ACA | (62, 2, 399, 161) | 12.48 | 3.58–76.76 | 7 × 10−7 |
flavonoid glycosides | ACA | (33, 4, 428, 159) | 3.06 | 1.15–10.28 | 0.032 |
saccharides | ACA | (14, 18, 447, 145) | 0.25 | 0.12–0.52 | 0.0002 |
amino acids | ACA | (9, 21, 452, 142) | 0.14 | 0.06–0.3 | 3 × 10−7 |
monoterpenoids | ACA | (21, 6, 440, 157) | 1.25 | 0.51–3.44 | 0.82 |
triterpenoids | ACA | (20, 2, 441, 161) | 3.65 | 0.97–23.34 | 0.082 |
coumarins | ACA | (20, 1, 441, 162) | 7.33 | 1.33–155.28 | 0.022 |
sesquiterpenoids | ACA | (18, 3, 443, 160) | 2.16 | 0.68–9.33 | 0.31 |
phenolic others | ACA | (16, 3, 445, 160) | 1.92 | 0.6–8.33 | 0.43 |
phenolic acids | ACA | (14, 4, 447, 159) | 1.24 | 0.42–4.45 | 1 |
short aliphatic acids | ACA | (9, 9, 452, 154) | 0.34 | 0.13–0.9 | 0.028 |
tannins | ACA | (14, 1, 447, 162) | 5.07 | 0.89–109.2 | 0.13 |
diterpenoids | ACA | (12, 2, 449, 161) | 2.15 | 0.54–14.29 | 0.54 |
sulfur compounds | ACA | (8, 6, 453, 157) | 0.46 | 0.15–1.45 | 0.21 |
monoterpenoid glycosides | ACA | (12, 1, 449, 162) | 4.32 | 0.74–94.12 | 0.2 |
steroid glycosides | ACA | (10, 1, 451, 162) | 3.59 | 0.59–79.2 | 0.3 |
fatty acids | ACA | (8, 2, 453, 161) | 1.42 | 0.32–9.89 | 1 |
phenolic acid esters | ACA | (7, 3, 454, 160) | 0.82 | 0.21–3.96 | 0.73 |
phenylpropanoids (others) * | ACA | (7, 3, 454, 160) | 0.82 | 0.21–3.96 | 0.73 |
triterpenoid glycosides | ACA | (9, 1, 452, 162) | 3.22 | 0.52–71.78 | 0.47 |
alkaloids | AIA | (74, 34, 437, 79) | 0.39 | 0.25–0.64 | 0.0002 |
flavonoids | AIA | (63, 1, 448, 112) | 15.72 | 3.03–324.24 | 5 × 10−5 |
flavonoid glycosides | AIA | (34, 3, 477, 110) | 2.61 | 0.87–10.89 | 0.12 |
saccharides | AIA | (16, 16, 495, 97) | 0.2 | 0.09–0.41 | 2 × 10−5 |
amino acids | AIA | (25, 5, 486, 108) | 1.11 | 0.44–3.33 | 1 |
monoterpenoids | AIA | (26, 1, 485, 112) | 5.99 | 1.11–125.95 | 0.043 |
triterpenoids | AIA | (19, 3, 492, 110) | 1.42 | 0.45–6.1 | 0.78 |
coumarins | AIA | (20, 1, 491, 112) | 4.56 | 0.83–96.63 | 0.15 |
sesquiterpenoids | AIA | (18, 3, 493, 110) | 1.34 | 0.42–5.79 | 0.78 |
phenolic others | AIA | (16, 3, 495, 110) | 1.18 | 0.37–5.17 | 1 |
phenolic acids | AIA | (16, 2, 495, 111) | 1.79 | 0.46–11.67 | 0.75 |
short aliphatic acids | AIA | (11, 7, 500, 106) | 0.33 | 0.13–0.93 | 0.029 |
tannins | AIA | (14, 1, 497, 112) | 3.15 | 0.55–68.05 | 0.33 |
diterpenoids | AIA | (13, 1, 498, 112) | 2.92 | 0.5–63.36 | 0.48 |
sulfur compounds | AIA | (10, 4, 501, 109) | 0.54 | 0.17–2.04 | 0.3 |
monoterpenoid glycosides | AIA | (12, 1, 499, 112) | 2.69 | 0.46–58.69 | 0.48 |
steroid glycosides | AIA | (8, 3, 503, 110) | 0.58 | 0.16–2.76 | 0.43 |
fatty acids | AIA | (7, 3, 504, 110) | 0.51 | 0.13–2.46 | 0.4 |
phenolic acid esters | AIA | (9, 1, 502, 112) | 2.01 | 0.32–44.8 | 0.7 |
phenylpropanoids (others) * | AIA | (8, 2, 503, 111) | 0.88 | 0.2–6.16 | 1 |
triterpenoid glycosides | AIA | (10, 0, 501, 113) | Infinity | __ | 0.22 |
Pooled Chemical Class | PDA | (a, b, c, d) | Odds Ratio (OR) | 95% Confidence Interval for OR | p-Value |
---|---|---|---|---|---|
alkaloids | AIA | (76, 34, 435, 79) | 0.41 | 0.25–0.66 | 0.0003 |
amino acids | AIA | (25, 5, 486, 108) | 1.11 | 0.44–3.33 | 1 |
coumarins | AIA | (22, 1, 489, 112) | 5.03 | 0.92–106.32 | 0.01 |
diterpenoids | AIA | (16, 1, 495, 112) | 3.62 | 0.64–77.5 | 0.33 |
fatty compounds | AIA | (16, 6, 495, 107) | 0.58 | 0.23–1.64 | 0.26 |
flavonoids | AIA | (97, 4, 414, 109) | 6.37 | 2.5–20.81 | 9 × 10−6 |
monoterpenoids | AIA | (48, 3, 463, 110) | 3.8 | 1.29–15.65 | 0.014 |
phenolic acids | AIA | (27, 3, 484, 110) | 2.04 | 0.67–8.62 | 0.33 |
phenolic others | AIA | (19, 3, 492, 110) | 1.42 | 0.45–6.1 | 0.78 |
phenylpropanoids | AIA | (9, 2, 502, 111) | 1 | 0.23–6.84 | 1 |
saccharides | AIA | (16, 16, 495, 97) | 0.2 | 0.09–0.41 | 2 × 10−5 |
sesquiterpenoids | AIA | (18, 5, 493, 108) | 0.79 | 0.3–2.43 | 0.59 |
short aliphatic acids | AIA | (11, 7, 500, 106) | 0.33 | 0.13–0.93 | 0.029 |
steroids | AIA | (13, 3, 498, 110) | 0.96 | 0.29–4.26 | 1 |
sulfur compounds | AIA | (10, 5, 501, 108) | 0.43 | 0.15–1.42 | 0.16 |
tannins | AIA | (14, 1, 497, 112) | 3.15 | 0.55–68.05 | 0.33 |
triterpenoids | AIA | (29, 3, 482, 110) | 2.2 | 0.73–9.26 | 0.24 |
alkaloids | ACA | (73, 37, 388, 126) | 0.64 | 0.41–1.01 | 0.056 |
amino acids | ACA | (9, 21, 452, 142) | 0.14 | 0.06–0.3 | 3 × 10−7 |
coumarins | ACA | (21, 2, 440, 161) | 3.84 | 1.03–24.49 | 0.055 |
diterpenoids | ACA | (13, 4, 448, 159) | 1.15 | 0.39–4.16 | 1 |
fatty compounds | ACA | (15, 7, 446, 156) | 0.75 | 0.3–2 | 0.62 |
flavonoids | ACA | (95, 6, 366, 157) | 6.78 | 3.08–17.41 | 5 × 10−8 |
monoterpenoids | ACA | (40, 11, 421, 152) | 1.31 | 0.67–2.73 | 0.51 |
phenolic acids | ACA | (23, 7, 438, 156) | 1.17 | 0.51–2.99 | 0.83 |
phenolic others | ACA | (19, 3, 442, 160) | 2.29 | 0.73–9.83 | 0.22 |
phenylpropanoids | ACA | (8, 3, 453, 160) | 0.94 | 0.25–4.44 | 1 |
saccharides | ACA | (14, 18, 447, 145) | 0.25 | 0.12–0.52 | 0.0002 |
sesquiterpenoids | ACA | (18, 5, 443, 158) | 1.28 | 0.49–3.93 | 0.81 |
short aliphatic acids | ACA | (9, 9, 452, 154) | 0.34 | 0.13–0.9 | 0.028 |
steroids | ACA | (15, 1, 446, 162) | 5.44 | 0.96–116.79 | 0.083 |
sulfur compounds | ACA | (8, 7, 453, 156) | 0.39 | 0.14–1.16 | 0.078 |
tannins | ACA | (14, 1, 447, 162) | 5.07 | 0.89–109.2 | 0.13 |
triterpenoids | ACA | (29, 3, 432, 160) | 3.58 | 1.19–14.97 | 0.024 |
Taste | (a, b, c, d) | Odds Ratio (OR) | 95% Confidence Interval for OR | p-Value |
---|---|---|---|---|
All tastes | (81, 32, 82, 429) | 13.16 | 8.25–21.32 | 3 × 10−30 |
Astringent | (9, 1, 8, 74) | 75.56 | 10.69–1847.1 | 3 × 10−7 |
Bitter | (40, 21, 50, 303) | 11.44 | 6.27–21.31 | 4 × 10−16 |
Pungent | (8, 4, 10, 60) | 11.45 | 2.93–51.13 | 0.0004 |
Sour | (10, 1, 9, 28) | 28.62 | 4.05–700.41 | 0.0001 |
Sweet | (22, 5, 23, 50) | 9.33 | 3.26–30.75 | 1 × 10−5 |
Chemical Class | (a, b, c, d) | Odds Ratio (OR) | 95% Confidence Interval for OR | p-Value |
---|---|---|---|---|
alkaloids | (24, 13, 10, 61) | 10.93 | 3.97–32.64 | 2 × 10−7 |
flavonoids | (1, 1, 0, 62) | Inf | 0.79–Inf | 0.031 |
flavonoid glycosides | (2, 2, 1, 32) | 25.21 | 0.98–1904.49 | 0.026 |
saccharides | (12, 6, 4, 10) | 4.73 | 0.89–30.52 | 0.073 |
amino acids | (5, 16, 0, 9) | Inf | 0.41-Inf | 0.29 |
monoterpenoids | (1, 5, 0, 21) | Inf | 0.09-Inf | 0.22 |
triterpenoids | (1, 1, 2, 18) | 7.55 | 0.08–738.06 | 0.26 |
coumarins | (0, 1, 1, 19) | 0 | 0–770.62 | 1 |
sesquiterpenoids | (2, 1, 1, 17) | 23.02 | 0.74–2065.5 | 0.041 |
phenolic others | (2, 1, 1, 15) | 20.38 | 0.65–1840.77 | 0.051 |
phenolic acids | (2, 2, 0, 14) | Inf | 0.75-Inf | 0.039 |
short aliphatic acids | (6, 3, 1, 8) | 13.25 | 1–819.63 | 0.05 |
tannins | (1, 0, 0, 14) | Inf | 0.36-Inf | 0.067 |
diterpenoids | (0, 2, 1, 11) | 0 | 0–233.15 | 1 |
sulfur compounds | (3, 3, 1, 7) | 5.99 | 0.33–417.16 | 0.24 |
monoterpenoid glycosides | (0, 1, 1, 11) | 0 | 0–464.61 | 1 |
steroid glycosides | (1, 0, 2, 8) | Inf | 0.07-Inf | 0.27 |
fatty acids | (1, 1, 2, 6) | 2.65 | 0.03–273.2 | 1 |
phenolic acid esters | (1, 2, 0, 7) | Inf | 0.06-Inf | 0.3 |
phenylpropanoids | (1, 2, 1, 6) | 2.65 | 0.03–273.2 | 1 |
triterpenoid glycosides | (0, 1, 0, 9) | 0 | 0-Inf | 1 |
No AIA/ACA | AIA/ACA | |
---|---|---|
No Taste/Chemical class | a | b |
Taste/Chemical class | c | d |
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Grădinaru, T.-C.; Gilca, M.; Vlad, A.; Dragoș, D. Relevance of Phytochemical Taste for Anti-Cancer Activity: A Statistical Inquiry. Int. J. Mol. Sci. 2023, 24, 16227. https://doi.org/10.3390/ijms242216227
Grădinaru T-C, Gilca M, Vlad A, Dragoș D. Relevance of Phytochemical Taste for Anti-Cancer Activity: A Statistical Inquiry. International Journal of Molecular Sciences. 2023; 24(22):16227. https://doi.org/10.3390/ijms242216227
Chicago/Turabian StyleGrădinaru, Teodora-Cristiana, Marilena Gilca, Adelina Vlad, and Dorin Dragoș. 2023. "Relevance of Phytochemical Taste for Anti-Cancer Activity: A Statistical Inquiry" International Journal of Molecular Sciences 24, no. 22: 16227. https://doi.org/10.3390/ijms242216227