Iron-Dependent Cell Death: A New Treatment Approach against Pancreatic Ductal Adenocarcinoma
Abstract
:1. Introduction
2. Reactive Oxygen Species Balance in PDAC
2.1. Generators of ROS
2.2. Scavengers of ROS
2.3. ROS Balance
3. ROS Exhibit Specific Biological Functions According to Different Molecular Subtypes of PDAC
3.1. The Squamous Molecular Subtype and ROS
3.2. The Progenitor Molecular Subtype and ROS
3.3. The Aberrantly Differentiated Endocrine-Exocrine (ADEX, Exocrine-Like) Subtype and ROS
3.4. The Immunogenic Subtype and ROS
4. Reactive Oxygen Species and Commonly Used Chemotherapy in PDAC
5. Potential Clinical Benefits of Ferroptosis Modulation in PDAC
5.1. Targeting Oxidants
5.2. Targeting Antioxidants
5.3. Combination Approaches
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Lopez-Blazquez, C.; Lacalle-Gonzalez, C.; Sanz-Criado, L.; Ochieng’ Otieno, M.; Garcia-Foncillas, J.; Martinez-Useros, J. Iron-Dependent Cell Death: A New Treatment Approach against Pancreatic Ductal Adenocarcinoma. Int. J. Mol. Sci. 2023, 24, 14979. https://doi.org/10.3390/ijms241914979
Lopez-Blazquez C, Lacalle-Gonzalez C, Sanz-Criado L, Ochieng’ Otieno M, Garcia-Foncillas J, Martinez-Useros J. Iron-Dependent Cell Death: A New Treatment Approach against Pancreatic Ductal Adenocarcinoma. International Journal of Molecular Sciences. 2023; 24(19):14979. https://doi.org/10.3390/ijms241914979
Chicago/Turabian StyleLopez-Blazquez, Carlos, Carlos Lacalle-Gonzalez, Lara Sanz-Criado, Michael Ochieng’ Otieno, Jesus Garcia-Foncillas, and Javier Martinez-Useros. 2023. "Iron-Dependent Cell Death: A New Treatment Approach against Pancreatic Ductal Adenocarcinoma" International Journal of Molecular Sciences 24, no. 19: 14979. https://doi.org/10.3390/ijms241914979