Cytokines in Systemic Lupus Erythematosus—Focus on TNF-α and IL-17
Round 1
Reviewer 1 Report
See the attachment, please.
Comments for author File: Comments.pdf
The comments are included in the main review file.
Author Response
Thank you for your help and understanding!
Author Response File: Author Response.docx
Reviewer 2 Report
In order for an acceptance of the work, I suggest same corrections to the authors
Line 29: SLE is an autoimmune disease based on the interaction between the innate and adaptive immune system, not correct.
It is better: SLE is an autoimmune disease based on the altered interaction between the innate and adaptive immune system.
Line 29: Broaden the introduction and general information about SLE, those reported are limited. The authors don’t speak about the role of TLRs, DCs, the IFN-I signature, NETosis that characterizes the disease, and not speak about any hypotheses present in literature on how tolerance to self is broken in the disease and of molecules capable of breaking self-tolerance in association with DNA (for example LL37). The multifactorial nature of SLE, due to genetic and predisposing factors but also to external factors are not considerate clearly. The abnormal production of TNF-α and IL-17 in SLE depend on the upstream mechanisms, which should be mentioned for better understanding the disease and to better contextualizing the cytokines under studies.
Line 79 and Fig 1: TNF receptors: describe better or do not put idem for line329 and figure 2
Line 186 to 195: In mice anti TNF drugs, has been shown different finding or good outcomes? It is not clear (contradiction). TNF administration has good effects in mice Lupus model, as reported by authors (conytradiction). Moreover, in SLE mice model there are also publications Contrary to anti TNF findings. Add data and references of different findings and write 2.4 more clearly, it not clear and contradictory
Line 200 and 220: Introduce more update bibliography if possible
Line 422. i suggedt to Add hypothesis about T reg can convert to IL 17 like cell under infiammatory condition exspecially the presence of IL6. It is possible that Th 17 cells could be diverted T reg cells. Anti IL 17 and IL 23 treatments could restore their function.
Author Response
Thank you for your help and understanding!
Author Response File: Author Response.docx
Round 2
Reviewer 1 Report
Dear Authors,
In my opiniom, the changes made manuscript much better.
Reviewer 2 Report
Now the work is good