Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s Disease
Abstract
:1. Alzheimer’s Disease
2. Pathology of Alzheimer’s Disease
3. Diets and Life Situations Negatively Influencing the Disease
3.1. Obesity and Malnutrition
3.2. Diet High in Fats
3.3. Western Diet
4. Diets with Positive Influence
4.1. Mediterranean Diet
4.2. DASH Diet
4.3. MIND Diet
4.4. Other Diets
4.4.1. Ketogenic Diet
4.4.2. Fasting
5. Beneficial Foods and Nutrients
5.1. Curcumin
5.2. Coffee and Tea
5.3. Cocoa
5.4. Vitamins
5.5. Foods Rising BDNF
6. Summary
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
References
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Authors | Type of Diet/Life Situation | Study Design | Study Population | Results | Reference |
---|---|---|---|---|---|
Lee et al. | Obesity | Pilot study | 10 obese patients before and after weight loss intervention | Changes in adipocyte APP expression correlated with changes in plasma Aβ40 levels (R = 0.74, p = 0.01). | [36] |
Ye et al. | Malnutrition | Longitudinal study | 747 patients with aMCI | The underweight group had a higher risk of probable Alzheimer’s disease dementia (pADD), and the decreased-BMI (HR: 2.29, 95% CI: 1.41–3.72) groups were at increased risk of progression to pADD. | [44] |
Hanson et al. | Malnutrition | Prospective cohort | 256 nursing home residents with advanced dementia and feeding problems | Significant mortality risk in patients with feeding problems | [45] |
Laitinen et al. | High-fat diet | Population-based study | 1449 patients with 117 who had dementia | Moderate intake of polyunsaturated fats in mid-life decreased the risk of dementia even after adjustment for demographic variables, especially among the ApoE epsilon4 carriers. | [54] |
Ruan et al. | High-fat diet | Meta-analysis of cohort studies | 8630 participants and 633 cases | A higher dietary saturated fat intake was significantly associated with increased risks of 39% and 105% for AD and dementia. | [55] |
Jacka et al. | Western diet | Longitudinal study | 255 persons from the Personality and Total Health Through Life Study | Higher consumption of an unhealthy “Western” dietary pattern was associated with smaller left hippocampal volume. | [67] |
Gibson et al. | Western diet | Observational study | 23 women with polycystic ovary syndrome from 25 to 45 years old | Greater intakes of saturated and trans fats, and higher saturated-to-unsaturated fat ratio (Sat:UFA) were associated with more errors in the visuospatial task and poorer word recall and recognition. | [62] |
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Doroszkiewicz, J.; Mroczko, J.; Rutkowski, P.; Mroczko, B. Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s Disease. Int. J. Mol. Sci. 2023, 24, 10751. https://doi.org/10.3390/ijms241310751
Doroszkiewicz J, Mroczko J, Rutkowski P, Mroczko B. Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s Disease. International Journal of Molecular Sciences. 2023; 24(13):10751. https://doi.org/10.3390/ijms241310751
Chicago/Turabian StyleDoroszkiewicz, Julia, Jan Mroczko, Piotr Rutkowski, and Barbara Mroczko. 2023. "Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s Disease" International Journal of Molecular Sciences 24, no. 13: 10751. https://doi.org/10.3390/ijms241310751