Spermatocytic Tumor: A Review
Abstract
:1. Introduction
2. Epidemiology
3. Pathophysiology
4. Histopathology
5. Clinical Features
6. Treatment
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Spermatocytic Tumor | Seminoma | |
---|---|---|
CD117/ckit | + | + |
D2-40/podoplanin | − | + |
OCT3/4 | − | + |
PLAP | − | + |
FGFR3 | + | − |
HRAS | + | − |
DMRT1 | + | − |
Spermatocytic Tumor | Seminoma | |
---|---|---|
Median Age (years) | 54 | 35 |
Frequency of all GCT (%) | <1% | 60% |
Presence of GCNIS | No | Yes |
Extragonadal site (% of all GCT) | No | 2–5% |
Expression of isochromosome 12p | Absent | Present |
Sarcomatous component | 5–8% | No |
Bilaterality (synchronous and metachronous) | 8–10% | 5% |
Stromal inflammatory reaction | Absent | Present |
Association to cryptorchidism | No | Yes |
Overall Survival at 5-y for Clinical Stage I (%) | 95% | 99% |
Overall Survival at 5-y for advanced disease (%) | Poor | 72–86% * |
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Secondino, S.; Viglio, A.; Neri, G.; Galli, G.; Faverio, C.; Mascaro, F.; Naspro, R.; Rosti, G.; Pedrazzoli, P. Spermatocytic Tumor: A Review. Int. J. Mol. Sci. 2023, 24, 9529. https://doi.org/10.3390/ijms24119529
Secondino S, Viglio A, Neri G, Galli G, Faverio C, Mascaro F, Naspro R, Rosti G, Pedrazzoli P. Spermatocytic Tumor: A Review. International Journal of Molecular Sciences. 2023; 24(11):9529. https://doi.org/10.3390/ijms24119529
Chicago/Turabian StyleSecondino, Simona, Alessandra Viglio, Giuseppe Neri, Giulia Galli, Carlotta Faverio, Federica Mascaro, Richard Naspro, Giovanni Rosti, and Paolo Pedrazzoli. 2023. "Spermatocytic Tumor: A Review" International Journal of Molecular Sciences 24, no. 11: 9529. https://doi.org/10.3390/ijms24119529