Polysialylation in a DISC1 Mutant Mouse
Abstract
:1. Introduction
2. Results
2.1. Design of Experiment
2.2. Comparison between WT and DISC1 Mutant Mice: Evaluation of the Immobility Rate and Concentration of Corticosterone in Serum
2.3. Evaluation of polySia (Glycan) Expression Based on 12E3, 735, and NCAM (Protein) Expression in the Brain
2.3.1. OB
2.3.2. PFC
2.3.3. SCN
2.3.4. AMG
2.3.5. HIP
3. Discussion
3.1. Immobility Ratio and Concentration of Corticosterone
3.2. Analysis of polySia and NCAM Expression in Five Different Brain Regions
3.2.1. OB
3.2.2. PFC
3.2.3. SCN
3.2.4. AMG
3.2.5. HIP
3.3. PolySia Expression and DISC1
4. Materials and Methods
4.1. Materials
4.2. Animals and Ethics Statement
4.3. TS Test
4.4. Sample Preparation
4.5. Corticosterone Quantification
4.6. Quantification of polySia and NCAM Using ELISA
4.7. Data Analysis
Author Contributions
Funding
Institutional Review Board Statement
Conflicts of Interest
References
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Takahashi, Y.; Abe, C.; Hane, M.; Wu, D.; Kitajima, K.; Sato, C. Polysialylation in a DISC1 Mutant Mouse. Int. J. Mol. Sci. 2022, 23, 5207. https://doi.org/10.3390/ijms23095207
Takahashi Y, Abe C, Hane M, Wu D, Kitajima K, Sato C. Polysialylation in a DISC1 Mutant Mouse. International Journal of Molecular Sciences. 2022; 23(9):5207. https://doi.org/10.3390/ijms23095207
Chicago/Turabian StyleTakahashi, Yuka, Chikara Abe, Masaya Hane, Di Wu, Ken Kitajima, and Chihiro Sato. 2022. "Polysialylation in a DISC1 Mutant Mouse" International Journal of Molecular Sciences 23, no. 9: 5207. https://doi.org/10.3390/ijms23095207