Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes

Otani, Kosuke; Funada, Hiroshi; Teranishi, Risa; Okada, Muneyoshi; Yamawaki, Hideyuki

doi:10.3390/ijms23084228

Open AccessArticle

Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes

by

Kosuke Otani

^†,

Hiroshi Funada

^†,

Risa Teranishi

,

Muneyoshi Okada

and

Hideyuki Yamawaki

^*

Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada 034-8628, Aomori, Japan

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2022, 23(8), 4228; https://doi.org/10.3390/ijms23084228

Submission received: 15 March 2022 / Revised: 7 April 2022 / Accepted: 8 April 2022 / Published: 11 April 2022

(This article belongs to the Special Issue 25th Anniversary of IJMS: Advances in Biochemistry)

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Abstract

Zucker fatty diabetes mellitus (ZFDM) rats harboring the missense mutation (fa) in a leptin receptor gene have been recently established as a novel animal model of obesity and type 2 diabetes (T2D). Here, we explored changes in cardiovascular dynamics including blood pressure and heart rate (HR) associated with the progression of obesity and T2D, as well as pathological changes in adipose tissue and kidney. There was no significant difference in systolic blood pressure (SBP) in ZFDM-Lepr^fa/fa (Homo) compared with ZFDM-Lepr^fa/+ (Hetero) rats, while HR and plasma adrenaline in Homo were significantly lower than Hetero. The mRNA expression of monocyte chemotactic protein-1 in perirenal white adipose tissue (WAT) from Homo was significantly higher than Hetero. Interscapular brown adipose tissue (BAT) in Homo was degenerated and whitened. The plasma blood urea nitrogen in Homo was significantly higher than Hetero. In summary, we demonstrated for the first time that HR and plasma adrenaline concentration but not SBP in Homo decrease with obesity and T2D. In addition, inflammation occurs in WAT from Homo, while whitening occurs in BAT. Further, renal function is impaired in Homo. In the future, ZFDM rats will be useful for investigating metabolic changes associated with the progression of obesity and T2D.

Keywords: cardiovascular dynamics; sympathetic nerve activity; obesity; diabetes; adipose tissue; kidney

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MDPI and ACS Style

Otani, K.; Funada, H.; Teranishi, R.; Okada, M.; Yamawaki, H. Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes. Int. J. Mol. Sci. 2022, 23, 4228. https://doi.org/10.3390/ijms23084228

AMA Style

Otani K, Funada H, Teranishi R, Okada M, Yamawaki H. Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes. International Journal of Molecular Sciences. 2022; 23(8):4228. https://doi.org/10.3390/ijms23084228

Chicago/Turabian Style

Otani, Kosuke, Hiroshi Funada, Risa Teranishi, Muneyoshi Okada, and Hideyuki Yamawaki. 2022. "Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes" International Journal of Molecular Sciences 23, no. 8: 4228. https://doi.org/10.3390/ijms23084228

APA Style

Otani, K., Funada, H., Teranishi, R., Okada, M., & Yamawaki, H. (2022). Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes. International Journal of Molecular Sciences, 23(8), 4228. https://doi.org/10.3390/ijms23084228

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes

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