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Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides

Department of Molecular Biochemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdansk, Poland
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Author to whom correspondence should be addressed.
Academic Editors: Davide Tagliazucchi and Serena Martini
Int. J. Mol. Sci. 2022, 23(6), 3068; https://doi.org/10.3390/ijms23063068
Received: 18 January 2022 / Revised: 24 February 2022 / Accepted: 10 March 2022 / Published: 12 March 2022
(This article belongs to the Special Issue Bioactive Peptides in Human Health and Disease)
Human neurohormone vasopressin (AVP) is synthesized in overlapping regions in the hypothalamus. It is mainly known for its vasoconstricting abilities, and it is responsible for the regulation of plasma osmolality by maintaining fluid homeostasis. Over years, many attempts have been made to modify this hormone and find AVP analogues with different pharmacological profiles that could overcome its limitations. Non-peptide AVP analogues with low molecular weight presented good affinity to AVP receptors. Natural peptide counterparts, found in animals, are successfully applied as therapeutics; for instance, lypressin used in treatment of diabetes insipidus. Synthetic peptide analogues compensate for the shortcomings of AVP. Desmopressin is more resistant to proteolysis and presents mainly antidiuretic effects, while terlipressin is a long-acting AVP analogue and a drug recommended in the treatment of varicose bleeding in patients with liver cirrhosis. Recently published results on diverse applications of AVP analogues in medicinal practice, including potential lypressin, terlipressin and ornipressin in the treatment of SARS-CoV-2, are discussed. View Full-Text
Keywords: vasopressin; vasopressin analogues; vasoconstrictors; vasopressin receptors; desmopressin vasopressin; vasopressin analogues; vasoconstrictors; vasopressin receptors; desmopressin
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MDPI and ACS Style

Glavaš, M.; Gitlin-Domagalska, A.; Dębowski, D.; Ptaszyńska, N.; Łęgowska, A.; Rolka, K. Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides. Int. J. Mol. Sci. 2022, 23, 3068. https://doi.org/10.3390/ijms23063068

AMA Style

Glavaš M, Gitlin-Domagalska A, Dębowski D, Ptaszyńska N, Łęgowska A, Rolka K. Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides. International Journal of Molecular Sciences. 2022; 23(6):3068. https://doi.org/10.3390/ijms23063068

Chicago/Turabian Style

Glavaš, Mladena, Agata Gitlin-Domagalska, Dawid Dębowski, Natalia Ptaszyńska, Anna Łęgowska, and Krzysztof Rolka. 2022. "Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides" International Journal of Molecular Sciences 23, no. 6: 3068. https://doi.org/10.3390/ijms23063068

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