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Review

An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells

1
Instituto de Neurociencias, Universidad Miguel Hernández—Consejo Superior de Investigaciones Científicas, 03550 San Juan de Alicante, Spain
2
The European University of Brain and Technology-NeurotechEU, 03550 San Juan de Alicante, Spain
3
Instituto de Investigación Biomédica y Sanitaria de Alicante, 03010 Alicante, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Takefumi Yamaguchi, Hiroshi Keino and Junko Hori
Int. J. Mol. Sci. 2022, 23(6), 2997; https://doi.org/10.3390/ijms23062997
Received: 8 February 2022 / Revised: 28 February 2022 / Accepted: 4 March 2022 / Published: 10 March 2022
(This article belongs to the Special Issue Immune Pathogenesis and Regulation of Ocular Inflammation)
The cornea is an avascular connective tissue that is crucial, not only as the primary barrier of the eye but also as a proper transparent refractive structure. Corneal transparency is necessary for vision and is the result of several factors, including its highly organized structure, the physiology of its few cellular components, the lack of myelinated nerves (although it is extremely innervated), the tightly controlled hydration state, and the absence of blood and lymphatic vessels in healthy conditions, among others. The avascular, immune-privileged tissue of the cornea is an ideal model to study the interactions between its well-characterized and dense sensory nerves (easily accessible for both focal electrophysiological recording and morphological studies) and the low number of resident immune cell types, distinguished from those cells migrating from blood vessels. This paper presents an overview of the corneal structure and innervation, the resident dendritic cell (DC) subpopulations present in the cornea, their distribution in relation to corneal nerves, and their role in ocular inflammatory diseases. A mouse model in which sensory axons are constitutively labeled with tdTomato and DCs with green fluorescent protein (GFP) allows further analysis of the neuro-immune crosstalk under inflammatory and steady-state conditions of the eye. View Full-Text
Keywords: corneal nerves; dendritic cells; neuro-immune interactions; ocular inflammation; ocular pain; animal models corneal nerves; dendritic cells; neuro-immune interactions; ocular inflammation; ocular pain; animal models
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MDPI and ACS Style

Frutos-Rincón, L.; Gómez-Sánchez, J.A.; Íñigo-Portugués, A.; Acosta, M.C.; Gallar, J. An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells. Int. J. Mol. Sci. 2022, 23, 2997. https://doi.org/10.3390/ijms23062997

AMA Style

Frutos-Rincón L, Gómez-Sánchez JA, Íñigo-Portugués A, Acosta MC, Gallar J. An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells. International Journal of Molecular Sciences. 2022; 23(6):2997. https://doi.org/10.3390/ijms23062997

Chicago/Turabian Style

Frutos-Rincón, Laura, José Antonio Gómez-Sánchez, Almudena Íñigo-Portugués, M. Carmen Acosta, and Juana Gallar. 2022. "An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells" International Journal of Molecular Sciences 23, no. 6: 2997. https://doi.org/10.3390/ijms23062997

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