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Review

Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications

1
Laboratory for Analytical Chemistry and Industrial Analysis, Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia
2
Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia
3
Department of Pharmacology, Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia
*
Author to whom correspondence should be addressed.
Academic Editor: Daniel Arcos
Int. J. Mol. Sci. 2022, 23(5), 2786; https://doi.org/10.3390/ijms23052786
Received: 15 February 2022 / Revised: 27 February 2022 / Accepted: 28 February 2022 / Published: 3 March 2022
(This article belongs to the Special Issue Research on Bone Healing Materials)
The unprecedented aging of the world’s population will boost the need for orthopedic implants and expose their current limitations to a greater extent due to the medical complexity of elderly patients and longer indwelling times of the implanted materials. Biocompatible metals with multifunctional bioactive coatings promise to provide the means for the controlled and tailorable release of different medications for patient-specific treatment while prolonging the material’s lifespan and thus improving the surgical outcome. The objective of this work is to provide a review of several groups of biocompatible materials that might be utilized as constituents for the development of multifunctional bioactive coatings on metal materials with a focus on antimicrobial, pain-relieving, and anticoagulant properties. Moreover, the review presents a summary of medications used in clinical settings, the disadvantages of the commercially available products, and insight into the latest development strategies. For a more successful translation of such research into clinical practice, extensive knowledge of the chemical interactions between the components and a detailed understanding of the properties and mechanisms of biological matter are required. Moreover, the cost-efficiency of the surface treatment should be considered in the development process. View Full-Text
Keywords: biomaterials; orthopedic implants; multifunctional coatings; drug delivery; antimicrobial; pain relief biomaterials; orthopedic implants; multifunctional coatings; drug delivery; antimicrobial; pain relief
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MDPI and ACS Style

Mastnak, T.; Maver, U.; Finšgar, M. Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications. Int. J. Mol. Sci. 2022, 23, 2786. https://doi.org/10.3390/ijms23052786

AMA Style

Mastnak T, Maver U, Finšgar M. Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications. International Journal of Molecular Sciences. 2022; 23(5):2786. https://doi.org/10.3390/ijms23052786

Chicago/Turabian Style

Mastnak, Tinkara, Uroš Maver, and Matjaž Finšgar. 2022. "Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications" International Journal of Molecular Sciences 23, no. 5: 2786. https://doi.org/10.3390/ijms23052786

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