Actions of Bisphenol A on Different Feto-Maternal Compartments Contributing to Preterm Birth

Vidal, Manuel S.; Menon, Ramkumar; Yu, Gracia Fe B.; Amosco, Melissa D.

doi:10.3390/ijms23052411

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Actions of Bisphenol A on Different Feto-Maternal Compartments Contributing to Preterm Birth

¹

College of Medicine, University of the Philippines Manila, Manila 1000, Philippines

²

Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA

³

Department of Biochemistry and Molecular Biology, University of the Philippines Manila, Manila 1000, Philippines

⁴

Department of Obstetrics and Gynecology, Philippine General Hospital, University of the Philippines Manila, Manila 1000, Philippines

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2022, 23(5), 2411; https://doi.org/10.3390/ijms23052411

Submission received: 5 January 2022 / Revised: 7 February 2022 / Accepted: 10 February 2022 / Published: 22 February 2022

(This article belongs to the Special Issue Environmental Exposure, Pregnancy, and Neonatal Outcomes)

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Abstract

Preterm birth remains to be one of the most prevalent obstetric complications worldwide. Since there are multiple etiological factors associated with this disease process, an integrative literature search in PubMed and Scopus databases on possible mechanism of action and effect of bisphenols on exposure on human or animal placental samples in preterm birth was conducted. From 2332 articles on initial literature search, 63 studies were included for full data extraction. Altogether, several pathways were shown to be possibly affected by bisphenols, leading to dysregulations in structural and endocrine foundation in the placenta, potential induction of senescence and failure of decidualization in the decidua, and possible propagation of inflammation in the fetal membranes. Combined, these actions may eventually counteract bisphenol-induced relaxation of the myometrium and promote contractility alongside fetal membrane weakening. In totality, these individual impairments in gestation-critical processes may lead to failure of maintenance of pregnancy, and thus effecting preterm birth.

Keywords: bisphenol; BPA; preterm birth; endocrine-disrupting compounds

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MDPI and ACS Style

Vidal, M.S., Jr.; Menon, R.; Yu, G.F.B.; Amosco, M.D. Actions of Bisphenol A on Different Feto-Maternal Compartments Contributing to Preterm Birth. Int. J. Mol. Sci. 2022, 23, 2411. https://doi.org/10.3390/ijms23052411

AMA Style

Vidal MS Jr., Menon R, Yu GFB, Amosco MD. Actions of Bisphenol A on Different Feto-Maternal Compartments Contributing to Preterm Birth. International Journal of Molecular Sciences. 2022; 23(5):2411. https://doi.org/10.3390/ijms23052411

Chicago/Turabian Style

Vidal, Manuel S., Jr., Ramkumar Menon, Gracia Fe B. Yu, and Melissa D. Amosco. 2022. "Actions of Bisphenol A on Different Feto-Maternal Compartments Contributing to Preterm Birth" International Journal of Molecular Sciences 23, no. 5: 2411. https://doi.org/10.3390/ijms23052411

APA Style

Vidal, M. S., Jr., Menon, R., Yu, G. F. B., & Amosco, M. D. (2022). Actions of Bisphenol A on Different Feto-Maternal Compartments Contributing to Preterm Birth. International Journal of Molecular Sciences, 23(5), 2411. https://doi.org/10.3390/ijms23052411

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Actions of Bisphenol A on Different Feto-Maternal Compartments Contributing to Preterm Birth

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