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Review

Modeling and Targeting Neuroglial Interactions with Human Pluripotent Stem Cell Models

1
Theranexus, 69008 Lyon, France
2
Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Labex Memolife, Université PSL, 75005 Paris, France
3
Université Paris-Saclay, Commissariat à l’Energie Atomique et aux Energies Alternatives, CNRS, Laboratoire des Maladies Neurodégénératives: Mécanismes, Thérapies, Imagerie, 92265 Fontenay-aux-Roses, France
4
Université Paris-Saclay, Commissariat à l’Energie Atomique et aux Energies Alternatives, Molecular Imaging Research Center, 92265 Fontenay-aux-Roses, France
*
Author to whom correspondence should be addressed.
Academic Editor: Rivka Ofir
Int. J. Mol. Sci. 2022, 23(3), 1684; https://doi.org/10.3390/ijms23031684
Received: 5 January 2022 / Revised: 26 January 2022 / Accepted: 30 January 2022 / Published: 31 January 2022
(This article belongs to the Special Issue hiPSC-Derived Cells as Models for Drug Discovery 2.0)
Generation of relevant and robust models for neurological disorders is of main importance for both target identification and drug discovery. The non-cell autonomous effects of glial cells on neurons have been described in a broad range of neurodegenerative and neurodevelopmental disorders, pointing to neuroglial interactions as novel alternative targets for therapeutics development. Interestingly, the recent breakthrough discovery of human induced pluripotent stem cells (hiPSCs) has opened a new road for studying neurological and neurodevelopmental disorders “in a dish”. Here, we provide an overview of the generation and modeling of both neuronal and glial cells from human iPSCs and a brief synthesis of recent work investigating neuroglial interactions using hiPSCs in a pathophysiological context. View Full-Text
Keywords: human pluripotent stem cells; neurons; astrocytes; microglia; neuroglial interactions; pathological modeling human pluripotent stem cells; neurons; astrocytes; microglia; neuroglial interactions; pathological modeling
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MDPI and ACS Style

Bigarreau, J.; Rouach, N.; Perrier, A.L.; Mouthon, F.; Charvériat, M. Modeling and Targeting Neuroglial Interactions with Human Pluripotent Stem Cell Models. Int. J. Mol. Sci. 2022, 23, 1684. https://doi.org/10.3390/ijms23031684

AMA Style

Bigarreau J, Rouach N, Perrier AL, Mouthon F, Charvériat M. Modeling and Targeting Neuroglial Interactions with Human Pluripotent Stem Cell Models. International Journal of Molecular Sciences. 2022; 23(3):1684. https://doi.org/10.3390/ijms23031684

Chicago/Turabian Style

Bigarreau, Julie, Nathalie Rouach, Anselme L. Perrier, Franck Mouthon, and Mathieu Charvériat. 2022. "Modeling and Targeting Neuroglial Interactions with Human Pluripotent Stem Cell Models" International Journal of Molecular Sciences 23, no. 3: 1684. https://doi.org/10.3390/ijms23031684

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