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p27, The Cell Cycle and Alzheimer´s Disease

Neurosciences Program, Center for Applied Medical Research (CIMA), University of Navarra and IdiSNA, 31008 Pamplona, Spain
Department of Pharmacology and Toxicology, University of Navarra and IdiSNA, 31008 Pamplona, Spain
Center for Nutrition Research and Department of Nutrition, Food Science and Physiology, University of Navarra and IdiSNA, 31008 Pamplona, Spain
CIBER Physiopathology of Obesity and Nutrition (CIBERobn), Carlos III Health Institute, 28029 Madrid, Spain
Author to whom correspondence should be addressed.
Academic Editor: Toshio Ohshima
Int. J. Mol. Sci. 2022, 23(3), 1211;
Received: 7 December 2021 / Revised: 18 January 2022 / Accepted: 20 January 2022 / Published: 21 January 2022
The cell cycle consists of successive events that lead to the generation of new cells. The cell cycle is regulated by different cyclins, cyclin-dependent kinases (CDKs) and their inhibitors, such as p27Kip1. At the nuclear level, p27Kip1 has the ability to control the evolution of different phases of the cell cycle and oppose cell cycle progression by binding to CDKs. In the cytoplasm, diverse functions have been described for p27Kip1, including microtubule remodeling, axonal transport and phagocytosis. In Alzheimer’s disease (AD), alterations to cycle events and a purported increase in neurogenesis have been described in the early disease process before significant pathological changes could be detected. However, most neurons cannot progress to complete their cell division and undergo apoptotic cell death. Increased levels of both the p27Kip1 levels and phosphorylation status have been described in AD. Increased levels of Aβ42, tau hyperphosphorylation or even altered insulin signals could lead to alterations in p27Kip1 post-transcriptional modifications, causing a disbalance between the levels and functions of p27Kip1 in the cytoplasm and nucleus, thus inducing an aberrant cell cycle re-entry and alteration of extra cell cycle functions. Further studies are needed to completely understand the role of p27Kip1 in AD and the therapeutic opportunities associated with the modulation of this target. View Full-Text
Keywords: cell cycle; Alzheimer’s disease; p27Kip1; neurogenesis; cytoplasm-nucleus shuttle cell cycle; Alzheimer’s disease; p27Kip1; neurogenesis; cytoplasm-nucleus shuttle
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MDPI and ACS Style

García-Osta, A.; Dong, J.; Moreno-Aliaga, M.J.; Ramirez, M.J. p27, The Cell Cycle and Alzheimer´s Disease. Int. J. Mol. Sci. 2022, 23, 1211.

AMA Style

García-Osta A, Dong J, Moreno-Aliaga MJ, Ramirez MJ. p27, The Cell Cycle and Alzheimer´s Disease. International Journal of Molecular Sciences. 2022; 23(3):1211.

Chicago/Turabian Style

García-Osta, Ana, Jinya Dong, María J. Moreno-Aliaga, and Maria J. Ramirez. 2022. "p27, The Cell Cycle and Alzheimer´s Disease" International Journal of Molecular Sciences 23, no. 3: 1211.

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