Next Article in Journal
The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges
Previous Article in Journal
Decoding the Phosphatase Code: Regulation of Cell Proliferation by Calcineurin
Previous Article in Special Issue
Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination
Article

Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells

1
Molecular Biosciences Graduate Program, College of Sciences and Mathematics, Arkansas State University, Jonesboro, AR 72467, USA
2
Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR 72467, USA
3
College of Agriculture, Arkansas State University, Jonesboro, AR 72467, USA
4
Department of Biological Sciences, Arkansas State University, Jonesboro, AR 72467, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Cornelia Braicu and Ancuta Jurj
Int. J. Mol. Sci. 2022, 23(3), 1139; https://doi.org/10.3390/ijms23031139
Received: 15 December 2021 / Revised: 13 January 2022 / Accepted: 18 January 2022 / Published: 20 January 2022
(This article belongs to the Special Issue Breast Cancer Mechanistic Insights and Targeted Therapies)
Triple-negative breast cancer (TNBC) is unresponsive to typical hormonal treatments, causing it to be one of the deadliest forms of breast cancer. Investigating alternative therapies to increase survival rates for this disease is essential. The goal of this study was to assess cytotoxicity and apoptosis mechanisms of prenylated stilbenoids in TNBC cells. The prenylated stilbenoids arachidin-1 (A-1) and arachidin-3 (A-3) are analogs of resveratrol (RES) produced in peanut upon biotic stress. The anticancer activity of A-1 and A-3 isolated from peanut hairy root cultures was determined in TNBC cell lines MDA-MB-231 and MDA-MB-436. After 24 h of treatment, A-1 exhibited higher cytotoxicity than A-3 and RES with approximately 11-fold and six-fold lower IC50, respectively, in MDA-MB-231 cells, and nine-fold and eight-fold lower IC50, respectively, in MDA-MB-436 cells. A-1 did not show significant cytotoxicity in the non-cancerous cell line MCF-10A. While A-1 blocked cell division in G2-M phases in the TNBC cells, it did not affect cell division in MCF-10A cells. Furthermore, A-1 induced caspase-dependent apoptosis through the intrinsic pathway by activating caspase-9 and PARP cleavage, and inhibiting survivin. In conclusion, A-1 merits further research as a potential lead molecule for the treatment of TNBC. View Full-Text
Keywords: triple-negative breast cancer; peanut; hairy roots; stilbenoids; prenylation; resveratrol; arachidin-1; arachidin-3; cell viability; apoptosis; flow cytometry triple-negative breast cancer; peanut; hairy roots; stilbenoids; prenylation; resveratrol; arachidin-1; arachidin-3; cell viability; apoptosis; flow cytometry
Show Figures

Graphical abstract

MDPI and ACS Style

Mohammadhosseinpour, S.; Ho, L.-C.; Fang, L.; Xu, J.; Medina-Bolivar, F. Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells. Int. J. Mol. Sci. 2022, 23, 1139. https://doi.org/10.3390/ijms23031139

AMA Style

Mohammadhosseinpour S, Ho L-C, Fang L, Xu J, Medina-Bolivar F. Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells. International Journal of Molecular Sciences. 2022; 23(3):1139. https://doi.org/10.3390/ijms23031139

Chicago/Turabian Style

Mohammadhosseinpour, Sepideh, Linh-Chi Ho, Lingling Fang, Jianfeng Xu, and Fabricio Medina-Bolivar. 2022. "Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells" International Journal of Molecular Sciences 23, no. 3: 1139. https://doi.org/10.3390/ijms23031139

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop