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Article

Osteopontin on the Dental Implant Surface Promotes Direct Osteogenesis in Osseointegration

1
Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8514, Japan
2
Research Center for Functional Materials, National Institute for Materials Science, Tsukuba 305-0047, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Marco Tatullo and Toshio Hattori
Int. J. Mol. Sci. 2022, 23(3), 1039; https://doi.org/10.3390/ijms23031039
Received: 6 December 2021 / Revised: 8 January 2022 / Accepted: 15 January 2022 / Published: 18 January 2022
(This article belongs to the Special Issue Advance in Research on Craniofacial Biology and Dentistry)
After dental implantation, osteopontin (OPN) is deposited on the hydroxyapatite (HA) blasted implant surface followed by direct osteogenesis, which is significantly disturbed in Opn-knockout (KO) mice. However, whether applying OPN on the implant surface promotes direct osteogenesis remains unclarified. This study analyzed the effects of various OPN modified protein/peptides coatings on the healing patterns of the bone-implant interface after immediately placed implantation in the maxilla of four-week-old Opn-KO and wild-type (WT) mice (n = 96). The decalcified samples were processed for immunohistochemistry for OPN and Ki67 and tartrate-resistant acid phosphatase histochemistry. In the WT mice, the proliferative activity in the HA binding peptide-OPN mimic peptide fusion coated group was significantly higher than that in the control group from day 3 to week 1, and the rates of OPN deposition and direct osteogenesis around the implant surface significantly increased in the recombinant-mouse-OPN (rOPN) group compared to the Gly-Arg-Gly-Asp-Ser peptide group in week 2. The rOPN group achieved the same rates of direct osteogenesis and osseointegration as those in the control group in a half period (week 2). None of the implant surfaces could rescue the direct osteogenesis in the healing process in the Opn-KO mice. These results suggest that the rOPN coated implant enhances direct osteogenesis during osseointegration following implantation. View Full-Text
Keywords: dental implants; maxilla; mice (knockout); osseointegration; osteopontin; titanium; tooth extraction dental implants; maxilla; mice (knockout); osseointegration; osteopontin; titanium; tooth extraction
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MDPI and ACS Style

Makishi, S.; Yamazaki, T.; Ohshima, H. Osteopontin on the Dental Implant Surface Promotes Direct Osteogenesis in Osseointegration. Int. J. Mol. Sci. 2022, 23, 1039. https://doi.org/10.3390/ijms23031039

AMA Style

Makishi S, Yamazaki T, Ohshima H. Osteopontin on the Dental Implant Surface Promotes Direct Osteogenesis in Osseointegration. International Journal of Molecular Sciences. 2022; 23(3):1039. https://doi.org/10.3390/ijms23031039

Chicago/Turabian Style

Makishi, Sanako, Tomohiko Yamazaki, and Hayato Ohshima. 2022. "Osteopontin on the Dental Implant Surface Promotes Direct Osteogenesis in Osseointegration" International Journal of Molecular Sciences 23, no. 3: 1039. https://doi.org/10.3390/ijms23031039

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