Potential Roles of Exosomes in the Development and Detection of Malignant Mesothelioma: An Update
Abstract
:1. Introduction
2. Malignant Mesothelioma and Exosomes
3. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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MM Samples/Specimens | Molecules (RNA, Proteins) in Exosomes | Core Findings | Reference |
---|---|---|---|
Human pleural effusions | Proteins and peptides | Known and new exosomal proteins SNX25, BTG1, PEDF, identified as biomarkers. | Bard et al., 2004 [24] |
Seven humani MM tumor cell lines | Proteomic cargo | Identified 38 proteins, confirmed 4 by immunoblot. New information on MM exosomes | Hegmans et al., 2004 [25] |
MM cell lines | Proteins, ligands | Immunological function of exosomes via NKG2D ligand expression | Clayton et al., 2005 [27] |
MM tumor bearing mice | Tumor associated antigens (TAA) | MM exosome show some promise in immunotherapy | Mahaweni et al., 2013 [28] |
MM cell lines and MM exosomes | Tunneling nanotubes (TnTs) | MM tumor cells form more TnTs in presence of exogenous exosomes. TnTs help in intercellular cargo transport | Thayanithy et al., 2014 [29] |
Four human MM cell lines | Proteins | Identified 2073 unique proteins in MM exosomes. Proteins could play important roles in cancer angiogenesis, metastasis, migration and immune regulation | Greening et al., 2016 [32] |
Six MM cell lines and 3 primary mesothelial cell lines | MM secretome proteins | MM secretome contained high abundance of exosomal proteins | Creaney et al., 2017 [34] |
Small cohort | microRNA | Specific exosomal miRNA signature can discriminate MM from past asbestos exposure subjects | Cavalleri et al., 2017 [36] |
Asbestos exposed lung epithelial cells, macrophages and mesothelial cells | Proteins and genes | Exosomes from asbestos exposed lung epithelial cells and macrophages can cause gene expression changes in mesothelial cells. | Munson et al., 2018 [39,42] |
Blood/serum from asbestos exposed mice | Proteins | Asbestos exposure caused increased abundance of certain proteins in serum exosomes. | Munson et al., 2019 [45] |
Human mesothelioma and mesothelial cells | microRNA | MM cells preferentially secrete tumor suppressor miRNA, miR16-5p via exosomes. Force feeding exosomes or inhibition of secretion of exosome is beneficial for death of MM tumor cells. | Munson et al., 2019 [45] |
Plasma from human MM patients | proteins | Exosome isolated were enriched with immunoglobulins. Study demonstrated that plasma-derived exosomal protein signature could be beneficial for cancer type detection | Hoshino et al., 2020 [46] |
Small number of MM patient sample | Proteins | Utility of exosomal protein signature in diagnosis of benign vs. malignant MM. | Javadi et al., 2021 [35] |
MM tumor stromal model. MM spheroids | microRNA | Exosomal transfer of miR-126 plays an anti-tumor response in MM. | Monaco et al., 2019 [37] Monaco et al., 2022 [38] |
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Munson, P.; Shukla, A. Potential Roles of Exosomes in the Development and Detection of Malignant Mesothelioma: An Update. Int. J. Mol. Sci. 2022, 23, 15438. https://doi.org/10.3390/ijms232315438
Munson P, Shukla A. Potential Roles of Exosomes in the Development and Detection of Malignant Mesothelioma: An Update. International Journal of Molecular Sciences. 2022; 23(23):15438. https://doi.org/10.3390/ijms232315438
Chicago/Turabian StyleMunson, Phillip, and Arti Shukla. 2022. "Potential Roles of Exosomes in the Development and Detection of Malignant Mesothelioma: An Update" International Journal of Molecular Sciences 23, no. 23: 15438. https://doi.org/10.3390/ijms232315438