Heterozygote Dopamine Transporter Knockout Rats Display Enhanced Cocaine Locomotion in Adolescent Females
Abstract
:1. Introduction
2. Results
2.1. Experiment 1: Characterization of DAT HET and KO Rat’s Phenotype and Response to Cocaine Administration
2.2. Experiment 2: Sensitization of Locomotor Activity to Cocaine in DAT Rats in the Open Field
2.3. Experiment 3: Dopamine Pathway Protein Alterations in DAT KO Rats
3. Discussion
4. Materials and Methods
4.1. Drugs
4.2. Animals
4.3. Immunoblot Analysis
4.4. Open Field (OF) Apparatus
4.5. Data Analyses
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Pardo, M.; Martin, M.; Gainetdinov, R.R.; Mash, D.C.; Izenwasser, S. Heterozygote Dopamine Transporter Knockout Rats Display Enhanced Cocaine Locomotion in Adolescent Females. Int. J. Mol. Sci. 2022, 23, 15414. https://doi.org/10.3390/ijms232315414
Pardo M, Martin M, Gainetdinov RR, Mash DC, Izenwasser S. Heterozygote Dopamine Transporter Knockout Rats Display Enhanced Cocaine Locomotion in Adolescent Females. International Journal of Molecular Sciences. 2022; 23(23):15414. https://doi.org/10.3390/ijms232315414
Chicago/Turabian StylePardo, Marta, Michele Martin, Raul R. Gainetdinov, Deborah C Mash, and Sari Izenwasser. 2022. "Heterozygote Dopamine Transporter Knockout Rats Display Enhanced Cocaine Locomotion in Adolescent Females" International Journal of Molecular Sciences 23, no. 23: 15414. https://doi.org/10.3390/ijms232315414