Osteoarthritis as an Umbrella Term for Different Subsets of Humans Undergoing Joint Degeneration: The Need to Address the Differences to Develop Effective Conservative Treatments and Prevention Strategies
Abstract
:1. Introduction
1.1. Background
1.2. Purpose of the Review
2. Subsets of Knee Osteoarthritis
2.1. Background
2.2. A Focus on Knee Osteoarthritis Associated with Knee Injury (Post-Traumatic Osteoarthritis; PTOA)
2.3. Metabolic OA
2.4. Post-Menopausal Onset Knee OA in Females
2.5. OA Risks Associated with Growth and Maturation Variations
3. Implications from Subtyping for Conservative Treatment for Knee OA
3.1. Background
3.2. OA Phenotyping and Conservative Care
4. The Way Forward
5. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Subtype | Initiation | Mechanical Instability a | Inflammation Detected b |
---|---|---|---|
PTOA | Joint Injury | YES | YES (due to injury/repair) |
Metabolic | Obesity | Not Initially | YES (metabolic syndrome) |
Post-Menopausal | Menopause | Not Initially | YES (with tissue degeneration) |
Growth/Maturation c | Age Transitions | Not Initially | YES (with tissue degeneration) |
(malalignment, muscle) | |||
Idiopathic d (cause?) | Aging?/Genetics? | Not Initially | YES (with tissue degeneration) |
All likely have some genetic risk associated with subtype and all present with pain and some disability |
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Hart, D.A. Osteoarthritis as an Umbrella Term for Different Subsets of Humans Undergoing Joint Degeneration: The Need to Address the Differences to Develop Effective Conservative Treatments and Prevention Strategies. Int. J. Mol. Sci. 2022, 23, 15365. https://doi.org/10.3390/ijms232315365
Hart DA. Osteoarthritis as an Umbrella Term for Different Subsets of Humans Undergoing Joint Degeneration: The Need to Address the Differences to Develop Effective Conservative Treatments and Prevention Strategies. International Journal of Molecular Sciences. 2022; 23(23):15365. https://doi.org/10.3390/ijms232315365
Chicago/Turabian StyleHart, David A. 2022. "Osteoarthritis as an Umbrella Term for Different Subsets of Humans Undergoing Joint Degeneration: The Need to Address the Differences to Develop Effective Conservative Treatments and Prevention Strategies" International Journal of Molecular Sciences 23, no. 23: 15365. https://doi.org/10.3390/ijms232315365