Crosstalk between microRNA and Oxidative Stress in Heart Failure: A Systematic Review
Abstract
:1. Introduction
1.1. microRNA
1.2. Oxidative Stress
1.2.1. ROS Origin, Formation, and Function
1.2.2. microRNA and Oxidative Stress in Cardiovascular Diseases
2. Materials and Methods
3. Results
3.1. Mitochondrial Integrity and Function
3.2. Antioxidant Defence
3.3. Iron Overload and Ferroptosis
3.4. Cardiac Hypertrophy and Remodelling
3.5. Apoptosis
3.6. Human Studies
3.7. Therapeutic Potential
3.7.1. miRNA-15b
3.7.2. miRNA-195
3.7.3. miRNA-27a
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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No. | miRNA | Ref. | Type of Study 1 | Techniqe 2 | Main Conclusion |
---|---|---|---|---|---|
3.1 Mitochondrial integrity and function | |||||
1 | miRNA-690 | Wang, X. et al. (2017) [24] | animal | RT qRT-PCR | microRNAs were enriched in mitochondria during heart failure, which establishes a link between microRNA and mitochondrion in heart failure. |
miRNA-696 | |||||
miRNA-532-5p | |||||
miRNA-345-3p | |||||
2 | miRNA-122 | Shi, Y. et al. (2021) [25] | animal | qRT-PCR with the miRCute Enhanced Fluorescence Quantitative Assay Kit (Tiangen) | miR-122 causes cardiomyocyte apoptosis by inhibiting Hand2 transcription factor and consequently increasing mitochondrial fission. This mechanism likely contributes to heart failure and modulating this pathway could be therapeutically valuable against heart failure. |
3 | miRNA-15b | Roy, S. et al. (2013) [26] | animal/in vivo | qRT-PCR | Suppression of inducible miRNA-15b can prevent rapid loss of cardiac function in an animal adult heart and can be a key approach worthy of therapeutic consideration. |
3.2 Antioxidant defence | |||||
4 | miRNA-27a | Tian, C. et al. (2018) [27] | animal/in vivo | qRT-PCR | Increased expression of local microRNAs induced by myocardial infarction may contribute to oxidative stress by the inhibition of nuclear factor erythroid 2-related factor 2(NRF2) translation in chronic heart failure. |
miRNA-28-3p | |||||
miRNA-34a | |||||
5 | miRNA-27a * | Tian, C. et al. (2020) [28] | animal/in vivo | qRT-PCR | Cardiac fibroblast-secretion of miRNA27a *-enriched extracellular vesicles (EV) might act as a paracrine signaling mediator of cardiac hypertrophy and may have a potential to become novel therapeutic target. |
6 | miRNA-24-3p | Shimizu, T. et al. (2020) [29] | animal | RNA-sequencing, western blot, ELISA | Protein kinase R–like endoplasmic reticulum (ER) kinase (PERK)-mediated suppression of miRNAs by sildenafil improves cardiac dysfunction in heart failure. |
3.3 Iron overload and ferroptosis | |||||
7 | miRNA-224-5p | Zheng, H. et al. (2021) [30] | animal | qRT-PCR, Western blot analysis, luciferase reporter assay | Circulatory RNA (circRNA), microRNA(miRNA) and mRNA work in a regulatory network and reveal potential targets for the treatment of heart failure. |
miRNA-296-3p | |||||
miRNA-671-5p | |||||
miRNA-1306-5p | |||||
miRNA-3082-5p | |||||
3.4 Cardiac hypertrophy and remodelling | |||||
8 | miRNA-21-3p | Zhao, Y. et al. (2018) [31] | animal | miRNA microarray, bioinforma-tic analysis, qRT-PCR, Western blot | The injection of Yiqifumai (YQFM) has a potential effect which alleviates cardiac hypertrophy and apoptosis in chronic heart failure by miRNA expression regulation. |
miRNA216-5p | |||||
miRNA-219a-2-3p | |||||
miRNA-381-3p | |||||
miRNA-466c-5p | |||||
miRNA-542-3p | |||||
miRNA-702-5p | |||||
9 | miRNA-93 | Su, Q. et al. (2019) [32] | animal/in vivo | RT qRT-PCR, ELISA, Western blot | Upregulated miR-93 and downregulated LIM domain kinase 1 (LIMK1) reduce cardiac dysfunction and improve ventricular remodelling in rats with chronic heart failure. |
10 | miRNA-142-5p | Sharma, S. et al. (2012) [33] | animal/in vivo | qRT-PCR, Western blot | Downregulation of miR-142 is a critical element of adaptive cardiac muscle hypertrophy in response to hemodynamic stress. |
miRNA-142-3p | |||||
11 | miRNA-195-5p | Shen, Y. et al. (2020) [34] | animal | RT qRT-PCR | Depleting miR-195-5p and up-regulating Chemokine receptor type 4 alleviates cardiac function injury in mice with heart failure and may be a potential candidate marker and therapeutic target for heart failure. |
For Section 3.4 see also research studies no.: 4 [27] and 5 [28]. | |||||
3.5 Apoptosis | |||||
12 | miRNA-454 | Wang, Y. et al. (2021) [35] | animal | RT qRT-PCR, Western blot | The cardioprotective role of miR-454 is achieved through activation of the cyclic adenosine 3′5′-monophosphate(cAMP). |
3.6 Human studies | |||||
13 | miRNA-129-5p | Ramachandran, S. et al. (2017) [36] | human | isolation of mir129-5p from plasma microvesicles, qRT-PCR | miR129-5p was found to be a sensitive and specific biomarker for heart failure in univentricular heart disease in pediatric patients independent of ventricular morphology or stage of palliation. |
14 | miRNA-208a | Mohammadi et al. (2021) [37] | human | qRT-PCR | The results on different populations of cardiovascular patients (after myocardial infarction, with arrhythmia, heart failure etc.) showed increases in both oxidative stress, inflammation, apoptotic factors, and in the expression of miR-208a. |
3.7 Therapeutic potential | |||||
15 | miRNA-15b | Roy, S. et al. (2013) [26] | animal/in vivo | qRT-PCR | Suppression of inducible miRNA-15b can prevent rapid loss of cardiac function in an animal adult heart and can be a key approach worthy of therapeutic consideration. |
For Section 3.5 see also research studies no.: 5 [28] and 11 [34]. |
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Klimczak-Tomaniak, D.; Haponiuk-Skwarlińska, J.; Kuch, M.; Pączek, L. Crosstalk between microRNA and Oxidative Stress in Heart Failure: A Systematic Review. Int. J. Mol. Sci. 2022, 23, 15013. https://doi.org/10.3390/ijms232315013
Klimczak-Tomaniak D, Haponiuk-Skwarlińska J, Kuch M, Pączek L. Crosstalk between microRNA and Oxidative Stress in Heart Failure: A Systematic Review. International Journal of Molecular Sciences. 2022; 23(23):15013. https://doi.org/10.3390/ijms232315013
Chicago/Turabian StyleKlimczak-Tomaniak, Dominika, Julia Haponiuk-Skwarlińska, Marek Kuch, and Leszek Pączek. 2022. "Crosstalk between microRNA and Oxidative Stress in Heart Failure: A Systematic Review" International Journal of Molecular Sciences 23, no. 23: 15013. https://doi.org/10.3390/ijms232315013